About: Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model

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About: Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model
Creator	Zhang, Xiaoyan Xu, Wei Chen, Ling Wang, Yang Zhang, Fan Wang, Qian Yu, Lei Zhang, Fuchun Zhao, Lingzhai Davidson, Edgar Zhang, Shengnan Chen, Peihai Feng, Liqiang Lei, Hui Li, Pingchao Liang, Renshan Liu, Xinglong Luo, Jia Lv, Huibin Niu, Xuefeng Pan, Weiqi Qu, Linbing Yan, Qihong Yao, Zhipeng Yi, Changhua Benjamin Doranz, Bryan, L
Source	Medline; PMC
abstract	The Zika virus (ZIKV) outbreak and its link to microcephaly triggered a public health concern. To examine antibody response in a patient infected with ZIKV, we used single-cell PCR to clone 31 heavy and light chain-paired monoclonal antibodies (mAbs) that bind to ZIKV envelope (E) proteins isolated from memory B cells of a ZIKV-infected patient. Three mAbs (7B3, 1C11, and 6A6) that showed the most potent and broad neutralization activities against the African, Asian, and American strains were selected for further analysis. mAb 7B3 showed an IC50 value of 11.6 ng/mL against the circulating American strain GZ02. Epitope mapping revealed that mAbs 7B3 and 1C11 targeted residue K394 of the lateral ridge (LR) epitope of the EDIII domain, but 7B3 has a broader LR epitope footprint and recognizes residues T335, G337, E370, and N371 as well. mAb 6A6 recognized residues D67, K118, and K251 of the EDII domain. Interestingly, although the patient was seronegative for DENV infection, mAb 1C11, originating from the VH3-23 and VK1-5 germline pair, neutralized both ZIKV and DENV1. Administration of the mAbs 7B3, 1C11, and 6A6 protected neonatal SCID mice infected with a lethal dose of ZIKV. This study provides potential therapeutic antibody candidates and insights into the antibody response after ZIKV infection.
has issue date	2019-05-25(xsd:dateTime)
bibo:doi	10.1080/22221751.2019.1614885
bibo:pmid	31130109
has license	cc-by
sha1sum (hex)	8377296478e62e2cd582fed23e9e20f512d5e92d
schema:url	https://doi.org/10.1080/22221751.2019.1614885
resource representing a document's title	Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model
has PubMed Central identifier	PMC6542155
has PubMed identifier	31130109
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:8377296478e62e2cd582fed23e9e20f512d5e92d#body_text
is schema:about of	named entity 'PROVIDES' named entity 'ADMINISTRATION' named entity 'D67' named entity 'GERMLINE' named entity 'ANTIBODY' named entity 'MICROCEPHALY' named entity 'EDIII' named entity 'VALUE' named entity 'LINK' named entity 'SINGLE' named entity 'ANALYSIS' named entity 'CELL' named entity 'PATIENT' named entity 'ITS' named entity 'TRIGGERED' named entity 'AFRICAN' named entity 'DIFFERENT' named entity 'PROTECTION' named entity 'B cells' named entity 'recognizes' named entity 'clone' named entity 'germline' named entity 'triggered' named entity 'health concern' named entity 'study' named entity 'patient' named entity 'single-cell' named entity 'mouse' named entity 'targeting' named entity 'protein' named entity 'TARGETING' named entity 'SELECTED' named entity 'EDII' named entity 'PAIRED' named entity 'PAIR' named entity 'CIRCULATING' named entity 'ANTIBODY RESPONSE' named entity 'ASIAN' named entity 'PCR' named entity 'MAB' named entity 'PROTEINS' named entity 'LETHAL DOSE' named entity 'RESIDUE' named entity 'POTENTIAL' named entity 'INFECTED' named entity 'AMERICAN' named entity 'SCID MICE' named entity 'INFECTION' named entity 'STUDY' named entity 'MOUSE MODEL' named entity 'MONOCLONAL ANTIBODIES' named entity 'PATIENT' named entity 'CONVALESCENT' named entity 'E PROTEIN' named entity 'EPITOPES'

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