About: Risk factors for the exacerbation of patients with 2019 Novel Coronavirus: A meta-analysis

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Risk factors for the exacerbation of patients with 2019 Novel Coronavirus: A meta-analysis
Creator	Li, Xiaosong Gao, Yao Huang, Wenxiang Zhao, Jinqiu
source	Medline; PMC
abstract	Many studies have reported the risk factors for exacerbations in patients with 2019 novel coronavirus (2019-nCoV). This study aims to perform the meta-analysis of risk factors for the exacerbation of the novel coronavirus-infected pneumonia (NCIP). PubMed, Embase and Google scholar have been searched. We included the cohort studies involving risk factors for the exacerbation of NCIP. This meta-analysis compared the risk factors of patients between intensive care (ICU) group and non-ICU group. Two cohort studies were included in this study. After comparing the patients between intensive care (ICU) group and non-ICU group, several important factors were found to significantly increase the risk of exacerbations in patients with NCIP, and they included hypertension (RR=2.34; 95% CI=1.21 to 4.51; P=0.01), cardiovascular diseases (RR=2.28; 95% CI=1.13 to 4.58; P=0.02), COPD (RR=7.65; 95% CI=1.24 to 47.13; P=0.03), dyspnea (RR=2.89; 95% CI=2.05 to 4.08; P<0.00001), myalgia or fatigue (RR=1.24; 95% CI=1.01 to 1.52; P=0.04), but several factors such as gender, Huanan Seafood Wholesale Market exposure, diabetes, chronic liver disease, malignancy, fever, cough, expectoration, headache and diarrhoea appeared to have no obvious effect on the exacerbation of pneumonia. In addition, as the exacerbation of pneumonia, some complications had the high probability to occur according to the meta-analysis of acute respiratory distress syndrome (ARDS) (RR=13.95; 95% CI=6.20 to 31.41; P<0.00001), shock (RR=24.29; 95% CI=4.66 to 126.69; P=0.0002), acute cardiac injury (RR=10.32; 95% CI=3.05 to 34.96; P=0.0002) and acute kidney injury (RR=5.90; 95% CI=1.32 to 26.35; P=0.02) between two groups. Several risk factors were confirmed to significantly improve the risk of exacerbation in patients with NCIP, which was very important for the exacerbation prediction and treatment of these patients.
has issue date	2020-07-06(xsd:dateTime)
bibo:doi	10.7150/ijms.47052
bibo:pmid	32714077
has license	cc-by
sha1sum (hex)	838fbe9743a4e8d4f8ce427d2cf082fa6a07b740
schema:url	https://doi.org/10.7150/ijms.47052
resource representing a document's title	Risk factors for the exacerbation of patients with 2019 Novel Coronavirus: A meta-analysis
has PubMed Central identifier	PMC7378653
has PubMed identifier	32714077
schema:publication	Int J Med Sci
resource representing a document's body	covid:838fbe9743a4e8d4f8ce427d2cf082fa6a07b740#body_text
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