About: Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys
Creator	Subbarao, Kanta Vogel, Leatrice Roberts, Anjeanette Murphy, Brian Zaki, Sherif Shieh, Wun-Ju Butler, Emily Fahle, Gary Fischer, Steven Mcauliffe, Josephine Claire, St, Marisa
topic	covid:83bd16888a0b6604c138764881849635dd35b564#this
Source	Elsevier; Medline; PMC
abstract	Abstract SARS coronavirus (SARS-CoV) administered intranasally and intratracheally to rhesus, cynomolgus and African Green monkeys (AGM) replicated in the respiratory tract but did not induce illness. The titer of serum neutralizing antibodies correlated with the level of virus replication in the respiratory tract (AGM>cynomolgus>rhesus). Moderate to high titers of SARS-CoV with associated interstitial pneumonitis were detected in the lungs of AGMs on day 2 and were resolving by day 4 post-infection. Following challenge of AGMs 2 months later, virus replication was highly restricted and there was no evidence of enhanced disease. These species will be useful for the evaluation of the immunogenicity of candidate vaccines, but the lack of apparent clinical illness in all three species, variability from animal to animal in level of viral replication, and rapid clearance of virus and pneumonitis in AGMs must be taken into account by investigators considering the use of these species in efficacy and challenge studies.
has issue date	2004-12-05(xsd:dateTime)
bibo:doi	10.1016/j.virol.2004.09.030
bibo:pmid	15527829
has license	els-covid
sha1sum (hex)	83bd16888a0b6604c138764881849635dd35b564
schema:url	https://doi.org/10.1016/j.virol.2004.09.030
resource representing a document's title	Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys
has PubMed Central identifier	PMC7111808
has PubMed identifier	15527829
schema:publication	Virology
resource representing a document's body	covid:83bd16888a0b6604c138764881849635dd35b564#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/83bd16888a0b6604c138764881849635dd35b564
is schema:about of	named entity 'RESTRICTED' named entity 'CANDIDATE' named entity 'RHESUS' named entity 'VIRAL REPLICATION' named entity 'VARIABILITY' named entity 'CYNOMOLGUS' named entity 'FOLLOWING' named entity 'VIRUS REPLICATION' named entity 'POST' named entity 'CORRELATED' named entity 'ADMINISTERED' named entity 'EVALUATION' named entity 'LATER' named entity 'INFECTION' named entity 'DAY 2' named entity 'AGM' named entity 'SARS-CoV' named entity 'REPLICATION' covid:arg/83bd16888a0b6604c138764881849635dd35b564 named entity 'INTERSTITIAL PNEUMONITIS' named entity 'NEUTRALIZING ANTIBODIES' named entity 'RHESUS' named entity 'CYNOMOLGUS MONKEYS' named entity 'NO EVIDENCE OF' named entity 'PNEUMONITIS' named entity 'SERUM' named entity 'ANIMAL' named entity 'DAY 4' named entity 'RAPID' named entity 'RESOLVING' named entity 'DETECTED' named entity 'MODERATE' named entity 'SARS CORONAVIRUS' named entity 'MONTHS' named entity 'SARS CORONAVIRUS' named entity 'AFRICAN GREEN' named entity 'AFRICAN GREEN MONKEYS' named entity 'DISEASE' named entity 'ILLNESS' named entity 'REPLICATED' named entity 'INVESTIGATORS' named entity 'HIGH' named entity 'LEVEL' named entity 'DID' named entity 'PUBLISHED' named entity 'INC' named entity 'RESPIRATORY TRACT' named entity 'ACCOUNT' named entity 'THE LUNGS' named entity 'ENHANCED' named entity 'SARS-COV' named entity 'IMMUNOGENICITY' named entity 'VIRUS' named entity 'CLINICAL' named entity 'TAKEN' named entity 'CLEARANCE' named entity 'RESPIRATORY TRACT' named entity 'ADMINISTERED' named entity 'INDUCE' named entity 'CHALLENGE' named entity 'USE OF' named entity 'BUT' named entity 'TITER' named entity 'APPARENT' named entity 'VACCINES' named entity 'STUDIES' named entity 'WITH ASSOCIATED' named entity 'CONSIDERING'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software