About: Association between renin–angiotensin–aldosterone system inhibitor treatment, neutrophil–lymphocyte ratio, D-Dimer and clinical severity of COVID-19 in hospitalized patients: a multicenter, observational study

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About: Association between renin–angiotensin–aldosterone system inhibitor treatment, neutrophil–lymphocyte ratio, D-Dimer and clinical severity of COVID-19 in hospitalized patients: a multicenter, observational study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association between renin–angiotensin–aldosterone system inhibitor treatment, neutrophil–lymphocyte ratio, D-Dimer and clinical severity of COVID-19 in hospitalized patients: a multicenter, observational study
Creator	Dagdelen, Sinan Degirmencioglu, Aleks Ekicibasi, Erkan Erdim, Refik Eroglu, Elif Gormez, Selcuk Pamukcu, Burak Paudel, Ashok Sariguzel, Nevin Burak, • Ceyda, • Gumusel, Kurtoglu Hilal, • Ibrahim, • Kirisoglu, Erel Tanboga, Halil
Source	Medline; PMC
abstract	The aim of this study was to investigate the possible relationship between worse clinical outcomes and the use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) in hospitalized COVID-19 patients. A total of 247 adult patients (154 males, 93 females; mean age: 51.3 ± 14.2 years) hospitalized for COVID-19 as confirmed by polymerase chain reaction (PCR) were retrospectively reviewed. Demographic and clinical characteristics and laboratory parameters were analyzed using various statistical modeling. Primary outcomes were defined as the need for intensive care unit (ICU), mechanical ventilation, or occurrence of death. Of the patients, 48 were treated in the ICU with a high flow oxygen/noninvasive mechanical ventilation (NIMV, n = 12) or mechanical ventilation (n = 36). Median length of ICU stay was 13 (range, 7–18) days. Mortality was seen in four of the ICU patients. Other patients were followed in the COVID-19 services for a median of 7 days. There was no significant correlation between the primary outcomes and use of ACEIs/ARBs (frequentist OR = 0.82, 95% confidence interval (CI) 0.29–2.34, p = 0.715 and Bayesian posterior median OR = 0.80, 95% CI 0.31–2.02) and presence of hypertension (frequentist OR = 1.23, 95% CI 0.52–2.92, p = 0.631 and Bayesian posterior median OR = 1.25, 95% CI 0.58–2.60). Neutrophil-to-lymphocyte ratio (NLR) and D-dimer levels were strongly associated with primary outcomes. In conclusion, the presence of hypertension and use of ACEIs/ARBs were not significantly associated with poor primary clinical outcomes; however, NLR and D-dimer levels were strong predictors of clinical worsening.
has issue date	2020-08-24(xsd:dateTime)
bibo:doi	10.1038/s41371-020-00405-3
bibo:pmid	32839534
has license	no-cc
sha1sum (hex)	83d1630d06dd4c9f738d671a1a4cf6aa8dfdfb69
schema:url	https://doi.org/10.1038/s41371-020-00405-3
resource representing a document's title	Association between renin–angiotensin–aldosterone system inhibitor treatment, neutrophil–lymphocyte ratio, D-Dimer and clinical severity of COVID-19 in hospitalized patients: a multicenter, observational study
has PubMed Central identifier	PMC7444679
has PubMed identifier	32839534
schema:publication	J Hum Hypertens
resource representing a document's body	covid:83d1630d06dd4c9f738d671a1a4cf6aa8dfdfb69#body_text
is schema:about of	named entity 'receptor' named entity 'D-dimer' named entity '95% CI' named entity 'levels' named entity 'Median' named entity 'ICU' named entity 'hypertension' named entity 'NLR' named entity 'D-Dimer' named entity 'multicenter' named entity 'Association' named entity 'DEMOGRAPHIC' named entity 'ADULT' named entity 'DAYS' named entity 'ENZYME INHIBITORS' named entity 'FOLLOWED' named entity 'STUDY' named entity 'SERVICES' named entity 'CLINICAL OUTCOMES' named entity 'mechanical ventilation' named entity 'chain reaction' named entity 'Primary' named entity 'patients' named entity 'treated' named entity 'strong' named entity '95% CI' named entity 'polymerase' named entity 'ARBs' named entity 'ARBs' named entity 'COVID-19' named entity 'mechanical ventilation' named entity 'hypertension' named entity 'PCR' named entity 'lymphocyte' named entity 'ICU' named entity 'D-dimer' named entity 'D-dimer' named entity 'COVID' named entity 'enzyme inhibitors' named entity 'COVID' named entity 'observational study' named entity 'D-Dimer' named entity 'NLR' named entity 'hypertension' named entity 'arrhythmia' named entity 'Austria' named entity 'D-dimer' named entity 'creatinine' named entity 'mechanical ventilation' named entity 'combination therapy' named entity 'missing data' named entity '3, 4' named entity 'mortality risk' named entity 'ACE inhibitors' named entity 'mortality rate' named entity 'ACE2' named entity 'mortality risk' named entity 'COVID-19' named entity 'COVID' named entity 'ferritin' named entity 'antihypertensive therapy' named entity 'SARS-CoV-2' named entity 'chronic obstructive pulmonary disease' named entity 'real-time polymerase chain reaction' named entity 'ARBs' named entity 'angiotensin receptor blocker'

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