About: Anti-TGEV Miller Strain Infection Effect of Lactobacillus plantarum Supernatant Based on the JAK-STAT1 Signaling Pathway

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About: Anti-TGEV Miller Strain Infection Effect of Lactobacillus plantarum Supernatant Based on the JAK-STAT1 Signaling Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Anti-TGEV Miller Strain Infection Effect of Lactobacillus plantarum Supernatant Based on the JAK-STAT1 Signaling Pathway
Creator	Yang, Yang Lu, Lu Wang, Kai Wu, Di Huang, Shilei Ran, Ling Song, Zhenhui Xie, Luyi Zhang, Yiling Zhang, Z Yu, Qiuhan Yan, Tao Kan, Zifei Niu, Zheng Changotra, Harish Del, Gabriela Kan, Niu Perdigon, Valle
Source	PMC
abstract	Transmissible gastroenteritis (TGE), caused by transmissible gastroenteritis virus (TGEV), is one many gastrointestinal inflections in piglets, characterized by diarrhea, and high mortality. Probiotics are ubiquitous bacteria in animal intestines, which have many functions, such as promoting intestinal peristalsis and maintaining the intestinal balance. We found that the supernatant of the Lp-1 strain of Lactobacillus plantarum, isolated in our laboratory, and named Lp-1s had marked anti-TGEV effect on IPEC-J2 cells. Lp-1s could induce large amounts of interferon-β in IPEC-J2 cells in the early stage (6 h) of infection with TGEV, and increased the level of phosphorylated signal transducer and activator of transcription and its nuclear translocation in the late stage (24–48 h) of infection. This resulted in upregulated expression of interferon-stimulated genes, and increased the transcription and protein expression of antiviral proteins, resulting in an anti-TGEV effect.
has issue date	2019-11-06(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.02540
bibo:pmid	31781061
has license	cc-by
sha1sum (hex)	83e2abcbaa73c0654cdfcd23bf817beeafbc6e37
schema:url	https://doi.org/10.3389/fmicb.2019.02540
resource representing a document's title	Anti-TGEV Miller Strain Infection Effect of Lactobacillus plantarum Supernatant Based on the JAK-STAT1 Signaling Pathway
has PubMed Central identifier	PMC6851170
has PubMed identifier	31781061
schema:publication	Front Microbiol
resource representing a document's body	covid:83e2abcbaa73c0654cdfcd23bf817beeafbc6e37#body_text
is schema:about of	named entity 'STAT1' named entity 'high' named entity 'translocation' named entity 'nuclear' named entity 'BASED' named entity 'MILLER' named entity 'PROBIOTICS' named entity 'EFFECT' named entity 'HAVE' named entity 'ITS' named entity 'STRAIN' named entity 'LABORATORY' named entity 'ANIMAL' named entity 'GASTROENTERITIS' named entity 'GENES' named entity 'SUPERNATANT' named entity 'ANTIVIRAL' named entity 'BACTERIA ' named entity 'TRANSCRIPTION' named entity 'BALANCE' named entity 'MAINTAINING' named entity 'LP-1' named entity 'OUR' named entity 'JAK' named entity 'SIGNALING PATHWAY' named entity 'STRAIN' named entity 'SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION' named entity 'PERISTALSIS' named entity 'INFECTION' named entity 'INFECTION' named entity 'LACTOBACILLUS PLANTARUM' named entity 'SUPERNATANT' named entity 'FOUND' named entity 'PROTEIN EXPRESSION' named entity 'FUNCTIONS' named entity 'ISOLATED' named entity 'NAMED' named entity 'EARLY STAGE' named entity 'LACTOBACILLUS PLANTARUM' named entity 'INFLECTIONS' named entity 'MORTALITY' named entity 'CHARACTERIZED' named entity 'UBIQUITOUS' named entity 'HIGH' named entity 'INTESTINAL' named entity 'MARKED' named entity 'PROTEINS' named entity 'PROMOTING' named entity 'RESULTING IN' named entity 'PHOSPHORYLATED' named entity 'INCREASED' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'GASTROINTESTINAL' named entity 'LEVEL' named entity 'INTESTINES' named entity 'EFFECT' named entity 'UPREGULATED EXPRESSION' named entity 'TGEV' named entity 'NUCLEAR TRANSLOCATION' named entity 'CELLS' named entity 'STIMULATED' named entity 'AMOUNTS' named entity 'DIARRHEA' named entity 'INDUCE'

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