About: Activation of Innate Immune-Response Genes in Little Brown Bats (Myotis lucifugus) Infected with the Fungus Pseudogymnoascus destructans

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About: Activation of Innate Immune-Response Genes in Little Brown Bats (Myotis lucifugus) Infected with the Fungus Pseudogymnoascus destructans Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Activation of Innate Immune-Response Genes in Little Brown Bats (Myotis lucifugus) Infected with the Fungus Pseudogymnoascus destructans
Creator	Misra, Vikram Rapin, Noreen Warnecke, Lisa Johns, Kirk Martin, Lauren Voyles, Jamie Bollinger, Trent Turner, James Willis, Craig
Source	PMC
abstract	Recently bats have been associated with the emergence of diseases, both as reservoirs for several new viral diseases in humans and other animals and, in the northern Americas, as hosts for a devastating fungal disease that threatens to drive several bat species to regional extinction. However, despite these catastrophic events little Information is available on bat defences or how they interact with their pathogens. Even less is known about the response of bats to infection during torpor or long-term hibernation. Using tissue samples collected at the termination of an experiment to explore the pathogenesis of White Nose Syndrome in Little Brown Bats, we determined if hibernating bats infected with the fungus Pseudogymnoascus destructans could respond to infection by activating genes responsible for innate immune and stress responses. Lesions due to fungal infection and, in some cases, secondary bacterial infections, were restricted to the skin. However, we were unable to obtain sufficient amounts of RNA from these sites. We therefore examined lungs for response at an epithelial surface not linked to the primary site of infection. We found that bats responded to infection with a significant increase in lungs of transcripts for Cathelicidin (an anti-microbial peptide) as well as the immune modulators tumor necrosis factor alpha and interleukins 10 and 23. In conclusion, hibernating bats can respond to experimental P. destructans infection by activating expression of innate immune response genes.
has issue date	2014-11-12(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0112285
bibo:pmid	25391018
has license	cc-by
sha1sum (hex)	84323c90f9a4e2e339105377d6a0769cc2fa0fbc
schema:url	https://doi.org/10.1371/journal.pone.0112285
resource representing a document's title	Activation of Innate Immune-Response Genes in Little Brown Bats (Myotis lucifugus) Infected with the Fungus Pseudogymnoascus destructans
has PubMed Central identifier	PMC4229191
has PubMed identifier	25391018
schema:publication	PLoS One
resource representing a document's body	covid:84323c90f9a4e2e339105377d6a0769cc2fa0fbc#body_text
is schema:about of	named entity 'activating' named entity 'epithelial' named entity 'drive' named entity 'expression' named entity 'Myotis lucifugus' named entity 'GENES' named entity 'BATS' named entity 'INFECTED' named entity 'SITES' named entity 'REGIONAL' named entity 'OBTAIN' named entity 'FUNGUS' named entity 'BAT' named entity 'PRIMARY SITE' named entity 'WHITE NOSE SYNDROME' named entity 'LUNGS' named entity 'CASES' named entity 'HOSTS' named entity 'GENES' named entity 'RESPONSIBLE' named entity 'FUNGAL DISEASE' named entity 'HIBERNATION' named entity 'IMMUNE MODULATORS' named entity 'PATHOGENESIS' named entity 'LITTLE' named entity 'ACTIVATING' named entity 'DUE TO' named entity 'EXPRESSION' named entity 'PEPTIDE' named entity 'NORTHERN' named entity 'SURFACE' named entity 'BROWN' named entity 'PSEUDOGYMNOASCUS DESTRUCTANS' named entity 'ACTIVATION' named entity 'IMMUNE-RESPONSE' named entity 'HUMANS' named entity 'SPECIES' named entity 'KNOWN' named entity 'EXAMINED' named entity 'DRIVE' named entity 'RESPOND TO' named entity 'EXPERIMENTAL' named entity 'RECENTLY' named entity 'INTERLEUKINS' named entity 'INFORMATION' named entity 'NEW' named entity 'RESPONSE' named entity 'BATS' named entity 'THEIR' named entity 'PATHOGENS' named entity 'TERMINATION' named entity 'INNATE IMMUNE RESPONSE' named entity 'FUNGAL INFECTION' named entity 'AVAILABLE' named entity 'TUMOR NECROSIS FACTOR ALPHA ' named entity 'SECONDARY' named entity 'HAVE' named entity 'STRESS' named entity 'TRANSCRIPTS' named entity 'RESPONSES' named entity 'IMMUNE' named entity 'ASSOCIATED WITH' named entity 'CATHELICIDIN' named entity 'HOW' named entity 'INCREASE' named entity 'FOUND' named entity 'RNA' named entity 'SAMPLES' named entity 'DETERMINED' named entity 'AMERICAS' named entity 'EXTINCTION' named entity 'AMOUNTS' named entity 'SUFFICIENT'

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