About: Giving the Genes a Shuffle: Using Natural Variation to Understand Host Genetic Contributions to Viral Infections

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Giving the Genes a Shuffle: Using Natural Variation to Understand Host Genetic Contributions to Viral Infections
Creator	Baric, Ralph Leist, Sarah
Source	Elsevier; Medline; PMC
abstract	The laboratory mouse has proved an invaluable model to identify host factors that regulate the progression and outcome of virus-induced disease. The paradigm is to use single-gene knockouts in inbred mouse strains or genetic mapping studies using biparental mouse populations. However, genetic variation among these mouse strains is limited compared with the diversity seen in human populations. To address this disconnect, a multiparental mouse population has been developed to specifically dissect the multigenetic regulation of complex disease traits. The Collaborative Cross (CC) population of recombinant inbred mouse strains is a well-suited systems-genetics tool to identify susceptibility alleles that control viral and microbial infection outcomes and immune responses and to test the promise of personalized medicine.
has issue date	2018-10-31(xsd:dateTime)
bibo:doi	10.1016/j.tig.2018.07.005
bibo:pmid	30131185
has license	els-covid
sha1sum (hex)	84556fa66ae1946bdc28f57a18e5ee89c2a1e97a
schema:url	https://doi.org/10.1016/j.tig.2018.07.005
resource representing a document's title	Giving the Genes a Shuffle: Using Natural Variation to Understand Host Genetic Contributions to Viral Infections
has PubMed Central identifier	PMC7114642
has PubMed identifier	30131185
schema:publication	Trends in Genetics
resource representing a document's body	covid:84556fa66ae1946bdc28f57a18e5ee89c2a1e97a#body_text
is schema:about of	named entity 'SHUFFLE' named entity 'GENETIC' named entity 'HOST' named entity 'NATURAL VARIATION' named entity 'USING' named entity 'GENES' named entity 'GIVING' named entity 'UNDERSTAND' named entity 'VIRAL INFECTIONS' named entity 'genetics' named entity 'genetic variation' named entity 'interdisciplinary' named entity 'QTL' named entity 'damage to DNA' named entity 'mouse models' named entity 'recombinant' named entity 'inbred strains' named entity 'Genomic locations' named entity 'sample size' named entity 'therapeutic treatment' named entity 'phenotype' named entity 'Nairobi' named entity 'complex traits' named entity 'human diseases' named entity 'genome sequences' named entity 'International Livestock Research Institute' named entity 'SARS-CoV' named entity 'obesity' named entity 'mutagens' named entity 'atherosclerosis' named entity 'leukocyte' named entity 'molecular markers' named entity '7:8' named entity 'candidate gene' named entity 'allele' named entity 'QTL' named entity 'neuroinvasive disease' named entity 'alleles' named entity 'Genetically engineered' named entity 'microbial pathogenesis' named entity 'scientific community' named entity 'bioinformatics' named entity 'gene' named entity 'virus' named entity 'alleles' named entity 'chromosomal regions' named entity 'mouse strains' named entity 'backcrossing' named entity 'genetic diversity' named entity 'genetic variant' named entity 'F1 hybrids' named entity 'inbred strains' named entity 'inbred mouse strains' named entity 'infectious disease' named entity 'phenotype' named entity 'gene variants' named entity 'C57BL/6J' named entity 'genotype-phenotype' named entity 'mouse strains' named entity 'mice' named entity 'pathogenesis' named entity 'mouse strains' named entity 'genotyped' named entity 'SARS' named entity 'Theiler's murine encephalomyelitis virus' named entity 'respiratory syncytial virus' named entity 'effector' named entity 'paradigm shift' named entity 'mice' named entity 'Forward genetics' named entity 'congenic' named entity 'inbreeding' named entity 'phenotypic' named entity 'irradiation' named entity 'genetic diversity' named entity 'rotavirus' named entity 'virus infections' named entity 'genome' named entity 'recombination' named entity 'host animal'

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