About: The C-terminal domain of Clostridium perfringens alpha toxin as a vaccine candidate against bovine necrohemorrhagic enteritis

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About: The C-terminal domain of Clostridium perfringens alpha toxin as a vaccine candidate against bovine necrohemorrhagic enteritis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The C-terminal domain of Clostridium perfringens alpha toxin as a vaccine candidate against bovine necrohemorrhagic enteritis
Creator	Deprez, Piet Haesebrouck, Freddy Pardon, Bart Valgaeren, Bonnie Goossens, Evy Van Immerseel, Filip Ducatelle, Richard Rodrigo-Mocholí, Diego Schauvliege, Stijn Timbermont, Leen Verherstraeten, Stefanie
source	Medline; PMC
abstract	Bovine necrohemorrhagic enteritis is caused by Clostridium perfringens and leads to sudden death. Alpha toxin, together with perfringolysin O, has been identified as the principal toxin involved in the pathogenesis. We assessed the potential of alpha toxin as a vaccine antigen. Using an intestinal loop model in calves, we investigated the protection afforded by antisera raised against native alpha toxin or its non-toxic C-terminal fragment against C. perfringens-induced intestinal necrosis. Immunization of calves with either of the vaccine preparations induced a strong antibody response. The resulting antisera were able to neutralize the alpha toxin activity and the C. perfringens-induced endothelial cytotoxicity in vitro. The antisera raised against the native toxin had a stronger neutralizing activity than those against the C-terminal fragment. However, antibodies against alpha toxin alone were not sufficient to completely neutralize the C. perfringens-induced necrosis in the intestinal loop model. The development of a multivalent vaccine combining the C-terminal fragment of alpha toxin with other C. perfringens virulence factors might be necessary for complete protection against bovine necrohemorrhagic enteritis.
has issue date	2016-04-27(xsd:dateTime)
bibo:doi	10.1186/s13567-016-0336-y
bibo:pmid	27121298
has license	cc-by
sha1sum (hex)	8466f11ac556bca1bac29ec93d802b49e020122f
schema:url	https://doi.org/10.1186/s13567-016-0336-y
resource representing a document's title	The C-terminal domain of Clostridium perfringens alpha toxin as a vaccine candidate against bovine necrohemorrhagic enteritis
has PubMed Central identifier	PMC4847199
has PubMed identifier	27121298
schema:publication	Vet Res
resource representing a document's body	covid:8466f11ac556bca1bac29ec93d802b49e020122f#body_text
is schema:about of	named entity 'Clostridium' named entity 'sudden death' named entity 'C. perfringens' named entity 'endothelial' named entity 'VIRULENCE FACTORS' named entity 'CAUSED BY' named entity 'ALPHA TOXIN' named entity 'involved' named entity 'antisera' named entity 'identified' named entity 'necrosis' named entity 'intestinal' named entity 'toxin' named entity 'cytotoxicity' named entity 'preparations' named entity 'antisera' named entity 'toxin' named entity 'pathogenesis' named entity 'C. perfringens' named entity 'antisera' named entity 'alpha toxin' named entity 'Alpha toxin' named entity 'enteritis' named entity 'multivalent vaccine' named entity 'cytotoxicity' named entity 'Clostridium perfringens alpha toxin' named entity 'antibody' named entity 'Alpha toxin' named entity 'alpha toxin' named entity 'necrotic' named entity 'bovine' named entity 'alpha toxin' named entity 'rCpa' named entity 'alpha toxin' named entity 'C-terminal domain' named entity 'toxin' named entity 'vaccine' named entity 'antibodies' named entity 'alpha toxin' named entity 'alpha toxin' named entity 'alpha toxin' named entity 'centrifugation' named entity 'paraffin wax' named entity 'vaccination' named entity 'C. perfringens' named entity 'recombinant' named entity 'immunization' named entity 'alpha toxin' named entity 'antisera' named entity 'collagenase' named entity 'Invitrogen' named entity 'rCpa' named entity 'C. perfringens' named entity 'hemolysis' named entity 'supernatant' named entity 'necrotic lesions' named entity 'bovine' named entity 'antigen' named entity 'wild-type' named entity 'Denmark' named entity 'antibody' named entity 'C. perfringens' named entity 'ampicillin' named entity 'C-terminal fragment' named entity 'alpha toxin' named entity 'shuttle vector' named entity 'adjuvant' named entity 'C-terminal domain' named entity 'C. perfringens' named entity 'antiserum' named entity 'C. perfringens'

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