About: Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide

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About: Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide
Creator	Tongaonkar, Prasad Tran, Patti Tran, Dat Beringer, Paul Laragione, Teresina Minond, Dmitriy Patel, Reshma Trinh, Katie Ouellette, André Schaal, Justin Selsted, Michael Fields, Gregg Gulko, Percio Roberts, Kevin Subramanian,
Source	Medline; PMC
abstract	θ-defensins constitute a family of macrocyclic peptides expressed exclusively in Old World monkeys. The peptides are pleiotropic effectors of innate immunity, possessing broad spectrum antimicrobial activities and immunoregulatory properties. Here we report that rhesus θ-defensin 1 (RTD-1) is highly effective in arresting and reversing joint disease in a rodent model of rheumatoid arthritis (RA). Parenteral RTD-1 treatment of DA/OlaHsd rats with established pristane-induced arthritis (PIA) rapidly suppressed joint disease progression, restored limb mobility, and preserved normal joint architecture. RTD-1 significantly reduced joint IL-1β levels compared with controls. RTD-1 dose-dependently inhibited fibroblast-like synoviocyte (FLS) invasiveness and FLS IL-6 production. Consistent with the inhibition of FLS invasiveness, RTD-1 was a potent inhibitor of arthritogenic proteases including ADAMs 17 and 10 which activate TNFα, and inhibited matrix metalloproteases, and cathepsin K. RTD-1 was non-toxic, non-immunogenic, and effective when administered as infrequently as once every five days. Thus θ-defensins, which are absent in humans, have potential as retroevolutionary biologics for the treatment of RA.
has issue date	2017-11-16(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0187868
bibo:pmid	29145473
has license	cc-by
sha1sum (hex)	848c234214cbc5eeb1d64a043ff097e32e8ebff0
schema:url	https://doi.org/10.1371/journal.pone.0187868
resource representing a document's title	Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide
has PubMed Central identifier	PMC5690597
has PubMed identifier	29145473
schema:publication	PLoS One
resource representing a document's body	covid:848c234214cbc5eeb1d64a043ff097e32e8ebff0#body_text
is schema:about of	named entity 'RESOLUTION' named entity 'immunity' named entity 'AUTOIMMUNE ARTHRITIS' named entity 'DEFENSIN' named entity 'ARTHRITIS' named entity 'POTENTIAL' named entity 'CATHEPSIN K' named entity 'ACTIVITIES' named entity 'BROAD SPECTRUM' named entity 'JOINT DISEASE' named entity 'HERE' named entity 'INHIBITOR' named entity 'NON-' named entity 'MOBILITY' named entity 'JOINT' named entity 'TNF' named entity 'ARCHITECTURE' named entity 'RTD' named entity 'REDUCED' named entity 'INHIBITION' named entity 'IMMUNOGENIC' named entity 'DISEASE PROGRESSION' named entity 'FIBROBLAST-LIKE SYNOVIOCYTE' named entity 'HUMANS' named entity 'ANTIMICROBIAL' named entity 'SUPPRESSED' named entity 'INFREQUENTLY' named entity 'FAMILY' named entity 'ABSENT' named entity 'INDUCED' named entity 'COMPARED' named entity 'METALLOPROTEASES' named entity 'DEFENSINS' named entity 'HAVE' named entity 'MODEL OF' named entity 'INCLUDING' named entity 'PROTEASES' named entity 'LEVELS' named entity 'TREATMENT' covid:arg/848c234214cbc5eeb1d64a043ff097e32e8ebff0 named entity 'HIGHLY' named entity 'IL-6 PRODUCTION' named entity 'PEPTIDE' named entity 'PARENTERAL' named entity 'ACTIVATE' named entity 'RHESUS' named entity 'IMMUNOMODULATORY' named entity 'SUPPRESSION' named entity 'RHESUS' named entity 'EXPRESSED' named entity 'RHEUMATOID ARTHRITIS' named entity 'REPORT' named entity 'IL-1' named entity 'EFFECTIVE' named entity 'NORMAL' named entity 'ESTABLISHED' named entity 'PRISTANE' named entity 'EVERY FIVE DAYS' named entity 'PRESERVED' named entity 'LIMB' named entity 'MATRIX' named entity 'INVASIVENESS' named entity 'PROPERTIES' named entity 'RATS' named entity 'DOSE' named entity 'CONSISTENT WITH' named entity 'INHIBITED'

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