About: Ultraviolet A light effectively reduces bacteria and viruses including coronavirus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Ultraviolet A light effectively reduces bacteria and viruses including coronavirus
Creator	Park, Jae Germano, Juliana Leite, Gabriela Mathur, Ruchi Melmed, Gil Morales, Walter Parodi, Gonzalo Pimentel, Mark Sakhaie, Siamak Sin, Jon Weitsman, Stacy Jesus Villanueva-Millan, Maria Kimid, Seung Rezaieid, Ali
source	Medline; PMC
abstract	Antimicrobial-resistant and novel pathogens continue to emerge, outpacing efforts to contain and treat them. Therefore, there is a crucial need for safe and effective therapies. Ultraviolet-A (UVA) phototherapy is FDA-approved for several dermatological diseases but not for internal applications. We investigated UVA effects on human cells in vitro, mouse colonic tissue in vivo, and UVA efficacy against bacteria, yeast, coxsackievirus group B and coronavirus-229E. Several pathogens and virally transfected human cells were exposed to a series of specific UVA exposure regimens. HeLa, alveolar and primary human tracheal epithelial cell viability was assessed after UVA exposure, and 8-Oxo-2'-deoxyguanosine was measured as an oxidative DNA damage marker. Furthermore, wild-type mice were exposed to intracolonic UVA as an in vivo model to assess safety of internal UVA exposure. Controlled UVA exposure yielded significant reductions in Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Enterococcus faecalis, Clostridioides difficile, Streptococcus pyogenes, Staphylococcus epidermidis, Proteus mirabilis and Candida albicans. UVA-treated coxsackievirus-transfected HeLa cells exhibited significantly increased cell survival compared to controls. UVA-treated coronavirus-229E-transfected tracheal cells exhibited significant coronavirus spike protein reduction, increased mitochondrial antiviral-signaling protein and decreased coronavirus-229E-induced cell death. Specific controlled UVA exposure had no significant effect on growth or 8-Oxo-2'-deoxyguanosine levels in three types of human cells. Single or repeated in vivo intraluminal UVA exposure produced no discernible endoscopic, histologic or dysplastic changes in mice. These findings suggest that, under specific conditions, UVA reduces various pathogens including coronavirus-229E, and may provide a safe and effective treatment for infectious diseases of internal viscera. Clinical studies are warranted to further elucidate the safety and efficacy of UVA in humans.
has issue date	2020-07-16(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0236199
bibo:pmid	32673355
has license	cc-by
sha1sum (hex)	84923a418e305313d017796fba1bca6516f2bc5b
schema:url	https://doi.org/10.1371/journal.pone.0236199
resource representing a document's title	Ultraviolet A light effectively reduces bacteria and viruses including coronavirus
has PubMed Central identifier	PMC7365468
has PubMed identifier	32673355
schema:publication	PLoS One
resource representing a document's body	covid:84923a418e305313d017796fba1bca6516f2bc5b#body_text
is schema:about of	named entity 'controls' named entity 'investigated' named entity 'cell' named entity 'survival' covid:arg/84923a418e305313d017796fba1bca6516f2bc5b named entity 'exposed' named entity 'Pseudomonas' named entity 'humans' named entity 'continue' named entity 'Proteus mirabilis' named entity 'dermatological' named entity 'UVA' named entity 'cells' named entity 'applications' named entity 'UVA' named entity 'safety' named entity 'levels' named entity 'coronavirus' named entity 'primary' named entity 'repeated' named entity 'mouse' named entity 'colonic' named entity 'exposed' named entity '8-Oxo-2'-deoxyguanosine' named entity 'tissue' named entity 'Therefore' named entity 'specific' named entity 'bacteria' named entity 'UVA' named entity 'reduces' named entity 'coxsackievirus' named entity 'epithelial cell' named entity 'HeLa' named entity 'pathogens' named entity 'Proteus mirabilis' named entity 'antiviral' named entity 'histologic' named entity 'mice' named entity 'coronavirus' named entity 'spike protein' named entity 'dermatological diseases' named entity 'intraluminal' named entity 'UVA' named entity 'UVA' named entity 'FDA' named entity 'UVA' named entity 'cell death' named entity 'ciliated' named entity 'isoflurane' named entity 'Sigma-Aldrich' named entity 'short-term' named entity 'antiviral' named entity 'EGFP' named entity 'transfected' named entity 'cell growth' named entity 't-test' named entity 'heatsink' named entity 'cell viability' named entity 'mucosal' named entity 'microbial' named entity 'UVA' named entity 'harmful effects' named entity 'COVID19' named entity 'Staphylococcus epidermidis' named entity 'EGFP' named entity 'endoscopy' named entity 'cell growth' named entity 'antiviral'

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