About: Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar)

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About: Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar)
Creator	Krasnov, Aleksei Aspehaug, Vidar Rimstad, Espen Dahle, Maria Lund, Morten Nyman, Ingvild Røsaeg, Magnus Timmerhaus, Gerrit
Source	Medline; PMC
abstract	Viral diseases are among the main challenges in farming of Atlantic salmon (Salmo salar). The most prevalent viral diseases in Norwegian salmon aquaculture are heart and skeletal muscle inflammation (HSMI) caused by Piscine orthoreovirus (PRV), and pancreas disease (PD) caused by Salmonid alphavirus (SAV). Both PRV and SAV target heart and skeletal muscles, but SAV additionally targets exocrine pancreas. PRV and SAV are often present in the same locations and co-infections occur, but the effect of this crosstalk on disease development has not been investigated. In the present experiment, the effect of a primary PRV infection on subsequent SAV infection was studied. Atlantic salmon were infected with PRV by cohabitation, followed by addition of SAV shedder fish 4 or 10 weeks after the initial PRV infection. Histopathological evaluation, monitoring of viral RNA levels and host gene expression analysis were used to assess disease development. Significant reduction of SAV RNA levels and of PD specific histopathological changes were observed in the co-infected groups compared to fish infected by SAV only. A strong correlation was found between histopathological development and expression of disease related genes in heart. In conclusion, experimentally PRV infected salmon are less susceptible to secondary SAV infection and development of PD. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13567-016-0389-y) contains supplementary material, which is available to authorized users.
has issue date	2016-10-21(xsd:dateTime)
bibo:doi	10.1186/s13567-016-0389-y
bibo:pmid	27769313
has license	cc-by
sha1sum (hex)	84befea7ee1f85d2e9367d83bdb4834d56f9682a
schema:url	https://doi.org/10.1186/s13567-016-0389-y
resource representing a document's title	Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar)
has PubMed Central identifier	PMC5075195
has PubMed identifier	27769313
schema:publication	Vet Res
resource representing a document's body	covid:84befea7ee1f85d2e9367d83bdb4834d56f9682a#body_text
is schema:about of	named entity 'aquaculture' named entity 'host' named entity 'diseases' named entity 'experimentally' named entity 'PRV' named entity 'mediates' named entity 'PROTECTION' named entity 'EXPERIMENTAL' named entity 'ALPHAVIRUS' named entity 'SALMON' named entity 'MONITORING' named entity 'SUBSEQUENT' named entity 'SPECIFIC' named entity 'SKELETAL MUSCLE INFLAMMATION' named entity 'DISEASE' named entity 'EVALUATION' named entity 'CAUSED BY' named entity 'VIRAL DISEASES' named entity 'ATLANTIC SALMON' named entity 'MAIN' named entity 'SALAR' named entity 'USED' named entity 'OCCUR' named entity 'EFFECT' named entity 'AQUACULTURE' named entity 'REDUCTION' named entity 'SUSCEPTIBLE' named entity 'TARGET' named entity 'BUT' named entity 'LOCATIONS' named entity 'RNA' named entity 'DISEASE RELATED' named entity 'FOLLOWED BY' named entity 'OBSERVED' named entity 'ASSESS' named entity 'EXOCRINE PANCREAS' named entity 'GENES' named entity 'EXPERIMENT' named entity 'CONCLUSION' named entity 'CHANGES' named entity 'SIGNIFICANT' named entity 'EXPRESSION' named entity 'LEVELS' named entity 'TARGETS' named entity 'SECONDARY' named entity 'STRONG' named entity 'ADDITION' named entity 'SAV' named entity 'FARMING' covid:arg/84befea7ee1f85d2e9367d83bdb4834d56f9682a named entity 'COMPARED' named entity 'INITIAL' named entity 'HISTOPATHOLOGICAL' named entity 'PRIMARY' named entity 'PANCREAS DISEASE' named entity 'INFECTION' named entity 'PISCINE ORTHOREOVIRUS' named entity 'INFECTION' named entity 'MEDIATES' named entity 'PANCREAS DISEASE' named entity 'CROSSTALK' named entity 'DEVELOPMENT' named entity 'INFECTED' named entity 'COHABITATION' named entity 'HEART' named entity 'GROUPS' named entity 'CORRELATION' named entity 'INVESTIGATED' named entity 'SALMONID' named entity 'GENE EXPRESSION ANALYSIS' named entity '10 WEEKS' named entity 'ATLANTIC SALMON' named entity 'FISH' named entity 'PISCINE ORTHOREOVIRUS'

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