About: Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

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About: Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues
Creator	Zhang, Yue Li, Lin Li, Meng-Yuan Wang, Xiao-Sheng
topic	covid:850af40c5b31c48e46731717f2b248c4c51c11ea#this
source	Medline; PMC
abstract	BACKGROUND: Since its discovery in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 2 180 000 people worldwide and has caused more than 150 000 deaths as of April 16, 2020. SARS-CoV-2, which is the virus causing coronavirus disease 2019 (COVID-19), uses the angiotensin-converting enzyme 2 (ACE2) as a cell receptor to invade human cells. Thus, ACE2 is the key to understanding the mechanism of SARS-CoV-2 infection. This study is to investigate the ACE2 expression in various human tissues in order to provide insights into the mechanism of SARS-CoV-2 infection. METHODS: We compared ACE2 expression levels across 31 normal human tissues between males and females and between younger (ages ≤ 49 years) and older (ages > 49 years) persons using two-sided Student’s t test. We also investigated the correlations between ACE2 expression and immune signatures in various tissues using Pearson’s correlation test. RESULTS: ACE2 expression levels were the highest in the small intestine, testis, kidneys, heart, thyroid, and adipose tissue, and were the lowest in the blood, spleen, bone marrow, brain, blood vessels, and muscle. ACE2 showed medium expression levels in the lungs, colon, liver, bladder, and adrenal gland. ACE2 was not differentially expressed between males and females or between younger and older persons in any tissue. In the skin, digestive system, brain, and blood vessels, ACE2 expression levels were positively associated with immune signatures in both males and females. In the thyroid and lungs, ACE2 expression levels were positively and negatively associated with immune signatures in males and females, respectively, and in the lungs they had a positive and a negative correlation in the older and younger groups, respectively. CONCLUSIONS: Our data indicate that SARS-CoV-2 may infect other tissues aside from the lungs and infect persons with different sexes, ages, and races equally. The different host immune responses to SARS-CoV-2 infection may partially explain why males and females, young and old persons infected with this virus have markedly distinct disease severity. This study provides new insights into the role of ACE2 in the SARS-CoV-2 pandemic.
has issue date	2020-04-28(xsd:dateTime)
bibo:doi	10.1186/s40249-020-00662-x
bibo:pmid	32345362
has license	cc-by
sha1sum (hex)	850af40c5b31c48e46731717f2b248c4c51c11ea
schema:url	https://doi.org/10.1186/s40249-020-00662-x
resource representing a document's title	Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues
has PubMed Central identifier	PMC7186534
has PubMed identifier	32345362
schema:publication	Infect Dis Poverty
resource representing a document's body	covid:850af40c5b31c48e46731717f2b248c4c51c11ea#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/850af40c5b31c48e46731717f2b248c4c51c11ea
is schema:about of	named entity 'digestive system' named entity 'females' named entity 'Results' named entity 'persons' named entity 'skin' named entity 'younger' named entity 'ACE2' named entity 'DISEASE SEVERITY' named entity 'PERSONS' named entity 'LIVER' named entity 'BLADDER' named entity 'INVADE' named entity 'FEMALES' named entity 'VIRUS' named entity 'NORMAL' named entity 'COLON' named entity 'MEDIUM' named entity 'ASSOCIATED WITH' covid:arg/850af40c5b31c48e46731717f2b248c4c51c11ea named entity 'tissues' named entity 'human tissues' named entity 'bone marrow' named entity 'brain' named entity 'tissues' named entity 'males' named entity 'infection' named entity 'infection' named entity 'compared' named entity 'signatures' named entity 'infect' named entity 'disease' named entity 'levels' named entity 'key' named entity 'SARS-CoV-2' named entity 'normal' named entity 'partially' named entity 'immune' named entity 'ACE2' named entity 'virus' named entity 'blood vessels' named entity 'thyroid' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'adipose tissue' named entity 'expression levels' named entity 'adrenal gland' named entity 'infection' named entity 'ACE2' named entity 'lungs' named entity 'blood vessels' named entity 'expression levels' named entity 'ACE2' named entity 'small intestine' named entity 'human tissues' named entity 'races' named entity 'SARS-CoV-2' named entity 'thyroid' named entity 'coronavirus infections' named entity 'NK cell' named entity 'ACE2' named entity 'small intestine' named entity 'testis' named entity 'CD247' named entity 'SARS-CoV-2' named entity 'gallbladder' named entity 'ACE2' named entity 'expression levels' named entity 'SARS-CoV-2' named entity 'infection' named entity 'respiratory tract' named entity 'SARS-CoV-2' named entity 'blood vessels' named entity 'ACE2' named entity 'protein' named entity 'expression levels'

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