About: Expanded skin virome in DOCK8-deficient patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Expanded skin virome in DOCK8-deficient patients
Creator	Conlan, Sean Huang, Xin Deming, Clay Lee-Lin, Shih-Queen Tirosh, Osnat Comparative, Nisc Program, Sequencing Su, Helen Freeman, Alexandra Kong, Heidi Segre #1, Julia
source	Medline; PMC
abstract	Human microbiome studies have revealed the intricate interplay of host immunity and bacterial communities to achieve homeostatic balance. Healthy skin microbial communities are dominated by bacteria with low viral representation(1–3), mainly bacteriophage. Specific eukaryotic viruses have been implicated in both common and rare skin diseases, but cataloging skin viral communities has been limited. Alterations in host immunity provide an opportunity to expand our understanding of microbial-host interactions. Primary immunedeficient patients manifest with various viral bacterial, fungal and parasitic infections, including skin infections(4). Dedicator of cytokinesis 8 (DOCK8) deficiency is a rare primary human immunodeficiency characterized by recurrent cutaneous and systemic infections, as well as atopy and cancer susceptibility(5). DOCK8, encoding a guanine nucleotide exchange factor highly expressed in lymphocytes, regulates actin cytoskeleton, which is critical for migration through collagen-dense tissues, such as skin(6). Analyzing deep metagenomic sequencing data from DOCK8-deficient skin samples demonstrated a notable increase in eukaryotic viral representation and diversity as compared to healthy volunteers. De novo assembly approaches identified hundreds of novel human papillomavirus genomes, illuminating microbial dark matter. Expansion of the skin virome in DOCK8-deficient patients underscores the importance of immune surveillance in controlling eukaryotic viral colonization and infection.
has issue date	2018-11-05(xsd:dateTime)
bibo:doi	10.1038/s41591-018-0211-7
bibo:pmid	30397357
has license	no-cc
sha1sum (hex)	850dc8add6efb76a6dc341cb7a5a236c1dd3da7c
schema:url	https://doi.org/10.1038/s41591-018-0211-7
resource representing a document's title	Expanded skin virome in DOCK8-deficient patients
has PubMed Central identifier	PMC6286253
has PubMed identifier	30397357
schema:publication	Nat Med
resource representing a document's body	covid:850dc8add6efb76a6dc341cb7a5a236c1dd3da7c#body_text
is schema:about of	named entity 'SKIN' named entity 'DOCK8' named entity 'EXPANDED ' named entity 'PATIENTS' named entity 'DEFICIENT' named entity 'virome' named entity 'Parainfluenza' named entity 'mutualistic interactions' named entity 'contigs' named entity 'Wilcoxon rank-sum test' named entity 'Blastn' named entity 'RNA-seq' named entity 'ThermoFisher' named entity 'A60' named entity 'systemic viral' named entity 'MCV' named entity 'follow-up' named entity 'PCR' named entity 'genus' named entity 'skin infections' named entity 'atopic dermatitis' named entity 'PCR' named entity 'microbial communities' named entity 'genome size' named entity 'nucleotide' named entity '16S rRNA gene' named entity 'phylogenetic tree' named entity 'amplicons' named entity 'herpes simplex virus 1' named entity 'Wilcoxon rank-sum test' named entity 'Polyomaviridae' named entity 'autosomal recessive' named entity 'HPV' named entity 'HPV' named entity 'HPV' named entity 'SNPs' named entity 'human skin' named entity 'Wilcoxon rank-sum test' named entity 'ac.uk' named entity 'rRNA' named entity 'immunosuppressed' named entity 'Metagenomic' named entity 'human papillomavirus' named entity 'Orthomyxoviridae' named entity 'genotype' named entity 'Papillomaviridae' named entity 'primers' named entity 'HPV' named entity 'statistical analyses' named entity 'viral infections' named entity 'metatranscriptomics' named entity 'RNA' named entity 'RNA' named entity 'virome' named entity 'correlation' named entity 'HPV' named entity 'primers' named entity 'HPV' named entity 'genome' named entity 'HPV' named entity 'HPV' named entity 'DOCK8' named entity 'contigs' named entity 'cutaneous' named entity 'sequence data' named entity 'microbiome' named entity 'papillomaviruses' named entity 'genus' named entity 'Sanger' named entity 'HPV' named entity 'low coverage'

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