About: Clinical Manifestations of Children with COVID-19: a Systematic Review

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Clinical Manifestations of Children with COVID-19: a Systematic Review
Creator	Antonio, José Brandão, Marcelo Pereira, Ricardo Barciela, Marcelo De Souza, Tiago Henrique De Souza, Tiago José, Roberto Mendes Pereira, Ricardo Nadal, Hersan Nadal, José Nogueira, Negrão Nogueira, Roberto
source	MedRxiv
abstract	Context: The coronavirus disease 2019 (COVID-19) outbreak is an unprecedented global public health challenge, leading to thousands of deaths every day worldwide. Despite the epidemiological importance, clinical patterns of children with COVID-19 remain unclear. Objective: To describe the clinical, laboratorial and radiological characteristics of children with COVID-19. Data Sources: The Medline database was searched between December 1st 2019 and March 30th 2020. Study Selection: Inclusion criteria were: (1) studied patients younger than 18 years old; (2) presented original data from cases of COVID-19 confirmed by reverse-transcription polymerase chain reaction; and (3) contained descriptions of clinical manifestations, laboratory tests or radiological examinations. Data Extraction: Number of cases, gender, age, clinical manifestations, laboratory tests, radiological examinations and outcomes. Results: A total of 34 studies (1,118 cases) were included. From all the cases, 1,111 had their severity classified: 14.3% were asymptomatic, 36.4% were mild, 46.0% were moderate, 2.2% were severe and 1.2% were critical. The most prevalent symptom was fever (16.3%), followed by cough (14.4%), nasal symptoms (3.6%), diarrhea (2.7%) and nausea/vomiting (2.5%). One hundred forty-five (12.9%) children were diagnosed with pneumonia and 43 (3.8%) upper airway infections were reported. Reduced lymphocyte count were reported in 13.1% of cases. Abnormalities on computed tomography was reported in 62.7% of cases. The most prevalent abnormalities reported were ground glass opacities, patchy shadows and consolidations. Only one death was reported. Conclusions: Clinical manifestations of children with COVID-19 differ widely from adults cases. Fever and respiratory symptoms should not be considered a hallmark of COVID-19 in children.
has issue date	2020-04-03(xsd:dateTime)
bibo:doi	10.1101/2020.04.01.20049833
has license	medrxiv
sha1sum (hex)	85d808959874239b8a82376b13485217b06bd61a
schema:url	https://doi.org/10.1101/2020.04.01.20049833
resource representing a document's title	Clinical Manifestations of Children with COVID-19: a Systematic Review
resource representing a document's body	covid:85d808959874239b8a82376b13485217b06bd61a#body_text
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