About: Host Single Nucleotide Polymorphisms Modulating Influenza A Virus Disease in Humans

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Host Single Nucleotide Polymorphisms Modulating Influenza A Virus Disease in Humans
Creator	Nogales, Aitor Dediego, Marta
Source	Medline; PMC
abstract	A large number of human genes associated with viral infections contain single nucleotide polymorphisms (SNPs), which represent a genetic variation caused by the change of a single nucleotide in the DNA sequence. SNPs are located in coding or non-coding genomic regions and can affect gene expression or protein function by different mechanisms. Furthermore, they have been linked to multiple human diseases, highlighting their medical relevance. Therefore, the identification and analysis of this kind of polymorphisms in the human genome has gained high importance in the research community, and an increasing number of studies have been published during the last years. As a consequence of this exhaustive exploration, an association between the presence of some specific SNPs and the susceptibility or severity of many infectious diseases in some risk population groups has been found. In this review, we discuss the relevance of SNPs that are important to understand the pathology derived from influenza A virus (IAV) infections in humans and the susceptibility of some individuals to suffer more severe symptoms. We also discuss the importance of SNPs for IAV vaccine effectiveness.
has issue date	2019-09-30(xsd:dateTime)
bibo:doi	10.3390/pathogens8040168
bibo:pmid	31574965
has license	cc-by
sha1sum (hex)	85efed2c84dba208203669ef115bb9dc750e24c1
schema:url	https://doi.org/10.3390/pathogens8040168
resource representing a document's title	Host Single Nucleotide Polymorphisms Modulating Influenza A Virus Disease in Humans
has PubMed Central identifier	PMC6963926
has PubMed identifier	31574965
schema:publication	Pathogens
resource representing a document's body	covid:85efed2c84dba208203669ef115bb9dc750e24c1#body_text
is schema:about of	named entity 'AFFECT' named entity 'INFECTION' named entity 'OPEN READING FRAMES' named entity 'LOCATED IN' named entity 'RESEARCH COMMUNITY' named entity 'IMMUNE RESPONSES' named entity 'MEDICAL' named entity 'COMPONENT' named entity 'IDENTIFICATION' named entity 'SUSCEPTIBILITY' named entity 'CONTAIN' named entity 'INFECTIOUS DISEASES' named entity 'APOPTOSIS' named entity 'VIRAL BUDDING' named entity 'SNPS' named entity 'PATHOLOGY' named entity 'CODING' named entity 'RELEVANCE' named entity 'REGIONS' named entity 'FRAMESHIFT' named entity 'RISK POPULATION' named entity 'GENETIC VARIATION' named entity 'INDUCED' named entity 'ACT' named entity 'CAPABILITY' named entity 'DIRECTLY' named entity 'PROCESSING' named entity 'SEVERITY' named entity 'VACCINE EFFECTIVENESS' named entity 'ADDITION' named entity 'CONSEQUENCE OF' named entity 'DIFFERENT' named entity 'HUMANS' named entity 'KIND' named entity 'X PROTEIN' named entity 'PRESENCE OF' named entity 'LARGE' named entity 'TO INHIBIT' named entity 'GAINED' named entity 'NS1' named entity 'ADVANTAGE' named entity 'USING' named entity 'IS A' named entity 'TO REGULATE' named entity 'RNA SYNTHESIS' named entity 'AVAILABLE' named entity 'SEVERE SYMPTOMS' named entity 'HOST' named entity 'NON-' named entity 'VIRAL INFECTIONS' named entity 'SUFFER' named entity 'ACTIVITY' named entity 'DISCUSS' named entity 'ENCODING' named entity 'EXPLORATION' named entity 'GENE EXPRESSION' named entity 'DNA SEQUENCE' named entity 'REPRESENT' named entity 'PROTEIN EXPRESSION' named entity 'FACTOR' named entity 'YEARS' named entity 'PATHOGENESIS' named entity 'HUMANS' named entity 'KEY' named entity 'NUMBER OF' named entity 'PUBLISHED' named entity 'INFLUENZA A VIRUS' named entity 'VIRAL' named entity 'SINGLE' named entity 'GENES' named entity 'PA MRNA' named entity 'VIRAL RNA' named entity 'MULTIPLE' named entity 'ASSOCIATION' named entity 'UNDERSTAND' named entity 'CELLULAR' named entity 'FUNCTIONS' named entity 'FOUND' named entity 'BLOCK' named entity 'HAVE'

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