About: Suppression of Virulent Porcine Epidemic Diarrhea Virus Proliferation by the PI3K/Akt/GSK-3α/β Pathway

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About: Suppression of Virulent Porcine Epidemic Diarrhea Virus Proliferation by the PI3K/Akt/GSK-3α/β Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Suppression of Virulent Porcine Epidemic Diarrhea Virus Proliferation by the PI3K/Akt/GSK-3α/β Pathway
Creator	Tong, Guangzhi Tong, Wu Yu, Hai Zhou, En-Min Shan, Tongling Kong, Ning Li, Guoxin Meng, Qiong Pan, Xi Wang, Zhongze Wu, Yongguang Yang, Shen Zheng, Hao Zuo, Yewen
topic	covid:8602709a812146a012e16df450b991f6343d2f46#this
Source	Medline; PMC
abstract	Porcine epidemic diarrhea virus (PEDV) has recently caused high mortality in suckling piglets with subsequent large economic losses to the swine industry. Many intracellular signaling pathways, including the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, are activated by viral infection. The PI3K/Akt pathway is an important cellular pathway that has been shown to be required for virus replication. In the present study, we found that the PEDV JS-2013 strain activated Akt in Vero cells at early (5–15 min) and late stages (8–10 h) of infection. Inhibiting PI3K, an upstream activator of Akt, enhanced PEDV replication. Inhibiting GSK-3α/β, one of the downstream effectors of PI3K/Akt pathway and regulated by Akt during PEDV infected Vero cells, also enhanced PEDV replication. Collectively, our data suggest that PI3K/Akt/GSK-3α/β signaling pathway is activated by PEDV and functions in inhibiting PEDV replication.
has issue date	2016-08-25(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0161508
bibo:pmid	27560518
has license	cc-by
sha1sum (hex)	8602709a812146a012e16df450b991f6343d2f46
schema:url	https://doi.org/10.1371/journal.pone.0161508
resource representing a document's title	Suppression of Virulent Porcine Epidemic Diarrhea Virus Proliferation by the PI3K/Akt/GSK-3α/β Pathway
has PubMed Central identifier	PMC4999130
has PubMed identifier	27560518
schema:publication	PLoS One
resource representing a document's body	covid:8602709a812146a012e16df450b991f6343d2f46#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/8602709a812146a012e16df450b991f6343d2f46
is schema:about of	named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'SUPPRESSION' named entity 'high' named entity 'inhibiting' named entity 'virus' named entity 'INTRACELLULAR SIGNALING' named entity 'LATE STAGES' named entity 'ECONOMIC' named entity 'SIGNALING PATHWAY' named entity 'ACTIVATOR OF' named entity 'INFECTION' named entity 'SIGNALING PATHWAYS' named entity 'DOWNSTREAM' named entity 'ONE OF' named entity '288' named entity 'CAUSED' named entity 'MORTALITY' named entity 'AND LATE' named entity 'GSK-3' named entity 'STUDY' named entity 'INDUSTRY' named entity 'IMPORTANT' named entity 'PATHWAY' named entity 'PI3K' named entity 'OUR' named entity 'HIGH' named entity 'RECENTLY' named entity 'EARLY' named entity 'SUGGEST' named entity 'VERO CELLS' named entity 'PATHWAY' named entity 'CELLULAR' named entity 'PHOSPHATIDYLINOSITOL 3-KINASE' named entity 'STRAIN' named entity 'DATA' named entity 'ACTIVATED' named entity 'REGULATED' named entity 'GSK-3' named entity 'UPSTREAM' named entity 'INFECTED' named entity 'PRESENT' named entity 'VIRULENT' named entity 'VIRUS PROLIFERATION' named entity 'PI3K' named entity 'ENHANCED' named entity 'INCLUDING' named entity 'INHIBITING' named entity 'MIN' named entity 'SWINE' named entity 'REPLICATION' named entity 'VIRUS REPLICATION' named entity 'LARGE' named entity 'FUNCTIONS' named entity 'AKT' named entity 'VIRAL INFECTION' named entity 'REQUIRED' named entity 'SUBSEQUENT' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' covid:arg/8602709a812146a012e16df450b991f6343d2f46 named entity 'replication' named entity 'data' named entity 'signaling pathway' named entity 'replication' named entity 'losses' named entity 'GSK-3α/β' named entity 'infection'

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