About: Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus
Creator	Zhou, Lei Ge, Xinna Guo, Xin Chen, Peng Gao, Peng Liu, Teng Chai, Yue Song, Jiangwei Hanid, Jun Yangid, Hanchun
Source	Medline; PMC
abstract	The unfolded protein response (UPR) in the endoplasmic reticulum (ER) constitutes a critical component of host innate immunity against microbial infections. In this report, we show that porcine reproductive and respiratory syndrome virus (PRRSV) utilizes the UPR machinery for its own benefit. We provide evidence that the virus targets the UPR central regulator GRP78 for proteasomal degradation via a mechanism that requires viral glycoprotein GP2a, while both IRE1-XBP1s and PERK-eIF2α-ATF4 signaling branches of the UPR are turned on at early stage of infection. The activated effector XBP1s was found to enter the nucleus, but ATF4 was unexpectedly diverted to cytoplasmic viral replication complexes by means of nonstructural proteins nsp2/3 to promote viral RNA synthesis. RNAi knockdown of either ATF4 or XBP1s dramatically attenuated virus titers, while overexpression caused increases. These observations reveal attractive host targets (e.g., ATF4 and XBP1s) for antiviral drugs and have implications in vaccine development.
has issue date	2019-11-18(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1008169
bibo:pmid	31738790
has license	cc-by
sha1sum (hex)	8666c802be0f784cd46d8a002832de0d7a2e62e5
schema:url	https://doi.org/10.1371/journal.ppat.1008169
resource representing a document's title	Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus
has PubMed Central identifier	PMC6932825
has PubMed identifier	31738790
schema:publication	PLoS Pathog
resource representing a document's body	covid:8666c802be0f784cd46d8a002832de0d7a2e62e5#body_text
is schema:about of	named entity 'proteasomal' named entity 'machinery' named entity 'cytoplasmic' named entity 'Talents' named entity 'program' named entity 'fund' named entity 'TALENTS' named entity 'NATURAL SCIENCE' named entity 'BUT' named entity 'NUCLEUS' named entity 'ENDOPLASMIC RETICULUM' named entity 'INCREASES' named entity 'SIGNALING' named entity 'MECHANISM' named entity 'MEANS' named entity 'CRITICAL' named entity 'REGULATOR' named entity 'OVEREXPRESSION' named entity 'REPORT' named entity 'EIF2' named entity 'ANTIVIRAL DRUGS' named entity 'ENTER' named entity 'BRANCHES' named entity 'BENEFIT' named entity 'ACTIVATED' named entity 'NSP2' named entity 'TURNED' named entity 'HAVE' named entity 'INFECTION' named entity 'CENTRAL' named entity 'VIRAL GLYCOPROTEIN' named entity 'ATTENUATED' named entity 'OBSERVATIONS' named entity 'EITHER' named entity 'PERK' named entity 'IRE1' named entity 'VIRAL REPLICATION' named entity 'EFFECTOR' named entity 'EARLY STAGE' named entity 'THESE' named entity 'COMPLEXES' named entity 'TARGETS' named entity 'PROVIDE' named entity 'RNAI KNOCKDOWN' named entity 'MACHINERY' named entity 'NONSTRUCTURAL PROTEINS' covid:arg/8666c802be0f784cd46d8a002832de0d7a2e62e5 named entity 'FOUNDATION' named entity 'RESEARCH' named entity 'FOUND' named entity 'CAUSED' named entity 'UNFOLDED PROTEIN RESPONSE' named entity 'SYSTEM' named entity 'THOUSAND' named entity 'PROGRAM' named entity 'CHINA' named entity 'AGRICULTURE' named entity 'COMPONENT' named entity 'REVEAL' named entity 'ATF4' named entity 'INFECTIONS' named entity 'INNATE IMMUNITY' named entity 'EVIDENCE' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'NATIONAL' named entity 'YOUTH' named entity 'ATTRACTIVE' named entity 'MICROBIAL' named entity 'PROMOTE' named entity 'VACCINE DEVELOPMENT' named entity 'DIVERTED' named entity 'ITS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software