About: Coronaviruses in spinal fluid of patients with acute monosymptomatic optic neuritis

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About: Coronaviruses in spinal fluid of patients with acute monosymptomatic optic neuritis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Coronaviruses in spinal fluid of patients with acute monosymptomatic optic neuritis
Creator	Dessau, R Dessau', R Frederiksen', J Lisby', G
Source	Medline; PMC
abstract	Acute monosymptomatic optic neuritis (AMON) may be an initial symptom of multiple sclerosis (MS). Coronaviruses have been implicated in the etiology of MS. The objective of the present study was to look for coronaviral RNA in AMON, which could be present in the initial stages of the development of MS. Material and methods ‐ Spinal fluids from 37 patients with AMON and 15 surgical control patients with protrusion of the intervertebral disk were assayed with a nested multiplex polymerase chain reaction with primers specific for human coronaviruses strain (HCV) 229E and OC43. Results ‐ Four patients and 1 control were positive for HCV‐229E. No evidence of HCV‐OC43 was found. The frequency of positive samples was low and there was no statistical difference between AMON and controls. Conclusion ‐ This study does not provide evidence for an etiological role of human coronaviruses in acute monosymptomatic optic neuritis.
has issue date	2009-01-29(xsd:dateTime)
bibo:doi	10.1111/j.1600-0404.1999.tb01043.x
bibo:pmid	10442448
has license	no-cc
sha1sum (hex)	867dc741b39eeb8967834774c6e41646b0c64cab
schema:url	https://doi.org/10.1111/j.1600-0404.1999.tb01043.x
resource representing a document's title	Coronaviruses in spinal fluid of patients with acute monosymptomatic optic neuritis
has PubMed Central identifier	PMC7159732
has PubMed identifier	10442448
schema:publication	Acta Neurol Scand
resource representing a document's body	covid:867dc741b39eeb8967834774c6e41646b0c64cab#body_text
is schema:about of	named entity 'SPINAL FLUID' named entity 'spinal fluid' named entity 'Dessau' named entity 'spinal fluid' named entity 'ACTA NEUROLOGICA SCANDINAVICA' named entity 'RNA' named entity 'PCR' named entity 'RNA' named entity 'coronaviruses' named entity 'primers' named entity '229E' named entity 'RT-PCR' named entity 'Southern blot' named entity 'RT-PCR' named entity 'electrophoresis' named entity 'primers' named entity 'multiple sclerosis' named entity 'agarose' named entity 'dyschromatopsia' named entity 'HCV' named entity 'mammal species' named entity 'intervertebral disk' named entity 'human coronaviruses' named entity 'neurological disease' named entity 'dATP' named entity 'RNA' named entity 'PCR' named entity 'supernatant' named entity 'porate' named entity 'polymerase chain reaction' named entity '229E' named entity 'nucleocapsid' named entity 'degenerative neurological diseases' named entity 'PCR' named entity 'PCR' named entity 'optic neuritis' named entity 'nucleotide' named entity 'RT-PCR' named entity 'PCR' named entity 'HCV' named entity 'primers' named entity 'primers' named entity 'multiplex PCR' named entity 'OC43' named entity 'virus' named entity 'human coronaviruses' named entity 'HCV' named entity 'HCV' named entity 'spinal fluid' named entity 'positive control' named entity 'primers' named entity 'PCR' named entity 'HCV' named entity 'Cetus' named entity 'nucleotide' named entity 'biotin' named entity 'serum samples' named entity 'ethanol' named entity 'Connecticut' named entity '229E' named entity 'HCV' named entity 'Cetus' named entity 'coronavirus' named entity 'Applied Biosystems' named entity 'OC43' named entity 'HCV' named entity '229E' named entity 'HCV' named entity '229E' named entity 'Reverse transcriptase' named entity 'virus' named entity 'assay' named entity 'HCV' named entity 'dTTP' named entity '229E' named entity 'annealing temperature' named entity 'uracil' named entity 'uracil'

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