About: Postnatal Persistent Infection with Classical Swine Fever Virus and Its Immunological Implications

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Postnatal Persistent Infection with Classical Swine Fever Virus and Its Immunological Implications
Creator	Summerfield, Artur Domingo, Mariano Ganges, Llilianne Muñoz-González, Sara Rosell, Rosa Montoya, Maria Ehrensperger, Felix Cordoba, Lorena Fraile, Lorenzo Frías-Leuporeau, Maria Pérez, Lester Ruggli,
Source	PMC
abstract	It is well established that trans-placental transmission of classical swine fever virus (CSFV) during mid-gestation can lead to persistently infected offspring. The aim of the present study was to evaluate the ability of CSFV to induce viral persistence upon early postnatal infection. Two litters of 10 piglets each were infected intranasally on the day of birth with low and moderate virulence CSFV isolates, respectively. During six weeks after postnatal infection, most of the piglets remained clinically healthy, despite persistent high virus titres in the serum. Importantly, these animals were unable to mount any detectable humoral and cellular immune response. At necropsy, the most prominent gross pathological lesion was a severe thymus atrophy. Four weeks after infection, PBMCs from the persistently infected seronegative piglets were unresponsive to both, specific CSFV and non-specific PHA stimulation in terms of IFN-γ-producing cells. These results suggested the development of a state of immunosuppression in these postnatally persistently infected pigs. However, IL-10 was undetectable in the sera of the persistently infected animals. Interestingly, CSFV-stimulated PBMCs from the persistently infected piglets produced IL-10. Nevertheless, despite the addition of the anti-IL-10 antibody in the PBMC culture from persistently infected piglets, the response of the IFN-γ producing cells was not restored. Therefore, other factors than IL-10 may be involved in the general suppression of the T-cell responses upon CSFV and mitogen activation. Interestingly, bone marrow immature granulocytes were increased and targeted by the virus in persistently infected piglets. Taken together, we provided the first data demonstrating the feasibility of CSFV in generating a postnatal persistent disease, which has not been shown for other members of the Pestivirus genus yet. Since serological methods are routinely used in CSFV surveillance, persistently infected pigs might go unnoticed. In addition to the epidemiological and economic significance of persistent CSFV infection, this model could be useful for understanding the mechanisms of viral persistence.
has issue date	2015-05-04(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0125692
bibo:pmid	25938664
has license	cc-by
sha1sum (hex)	87620b2fa94ff9b59a3a84382dceae62f83259a6
schema:url	https://doi.org/10.1371/journal.pone.0125692
resource representing a document's title	Postnatal Persistent Infection with Classical Swine Fever Virus and Its Immunological Implications
has PubMed Central identifier	PMC4418595
has PubMed identifier	25938664
schema:publication	PLoS One
resource representing a document's body	covid:87620b2fa94ff9b59a3a84382dceae62f83259a6#body_text
is schema:about of	named entity 'IL-10' named entity 'Two' named entity 'PBMCs' named entity 'However' named entity 'isolates' named entity 'Virus' covid:arg/87620b2fa94ff9b59a3a84382dceae62f83259a6 named entity 'OFFSPRING' named entity 'UNDETECTABLE' named entity 'PERSISTENT DISEASE' named entity 'INFECTED' named entity 'USED' named entity 'HEALTHY' named entity 'ITS' named entity 'TARGETED' named entity 'PBMC' named entity 'PRESENT' named entity 'ADDITION' named entity 'WAS A' named entity 'PERSISTENT' named entity 'INFECTION' named entity 'POSTNATAL' named entity 'STATE' named entity 'SEROLOGICAL' named entity 'PROMINENT' named entity 'IMMUNOSUPPRESSION' named entity 'RESPONSE' named entity 'ISOLATES' named entity 'NON-SPECIFIC' named entity 'MID' named entity 'UNRESPONSIVE TO' named entity 'NECROPSY' named entity 'CELLS' named entity 'SERUM' named entity 'ESTABLISHED' named entity 'GROSS' named entity 'LESION' named entity 'CELLULAR IMMUNE RESPONSE' named entity 'HIGH' named entity 'PROVIDED' named entity 'TAKEN' named entity 'IL-10' named entity 'DATA' named entity 'T-CELL' named entity 'SERONEGATIVE' named entity 'MOUNT' named entity 'ABILITY' named entity 'POSTNATAL' named entity 'CLASSICAL SWINE FEVER VIRUS' named entity 'IMMUNOLOGICAL' named entity 'PERSISTENT INFECTION' named entity 'SURVEILLANCE' named entity 'AIM' named entity 'LOW' named entity 'THYMUS ATROPHY' named entity 'CULTURE' named entity 'TERMS' named entity 'PERSISTENTLY' named entity 'GESTATION' named entity 'POSTNATAL INFECTION' named entity 'METHODS' named entity 'DEVELOPMENT' named entity 'STIMULATED' named entity 'PATHOLOGICAL' named entity 'MAY BE' named entity 'SPECIFIC' named entity 'MOST OF' named entity 'INDUCE' named entity 'DETECTABLE' named entity 'PESTIVIRUS'

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