About: VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses

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About: VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses
Creator	Merits, Andres Utt, Age Carissimo, Guillaume Chan, Yi-Hao Chua, Tze-Kwang Adachi, Akio Ng, Lisa Abu Bakar, Farhana Defilippis, Victor Galbraith, Sareen
Source	Medline; PMC
abstract	The evolutionarily conserved AAA+ ATPase valosin-containing protein (VCP) was previously shown to be a proviral host factor for several viruses from different viral families such as Flaviviridae, Picornaviridae, and Herpesviridae. VCP was shown to affect trafficking of Sindbis virus receptor and functions as a component of Semliki Forest virus (SFV) replicase compartment. However, the role of this cellular protein was not evaluated during replication of alphaviruses including chikungunya virus (CHIKV). Using siRNA, chemical inhibitors, and trans-replication assays, we show here that VCP is a proviral factor involved in the replication of CHIKV. Immunofluorescence assays confirmed that VCP co-localized with non-structural replicase proteins but not with dsRNA foci possibly due to VCP epitope unavailability. VCP pro-viral role is also observed with other alphaviruses such as o’nyong’nyong virus (ONNV) and SFV in different human cell lines. VCP proviral roles on several viral families now extend to replication of alphaviruses CHIKV and ONNV, emphasizing the pivotal role of VCP in virus–host interaction biology.
has issue date	2019-09-24(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.02236
bibo:pmid	31636613
has license	cc-by
sha1sum (hex)	8778a5efe2618f5d7c1873b4f1d6c6b49464e2c6
schema:url	https://doi.org/10.3389/fmicb.2019.02236
resource representing a document's title	VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses
has PubMed Central identifier	PMC6787436
has PubMed identifier	31636613
schema:publication	Front Microbiol
resource representing a document's body	covid:8778a5efe2618f5d7c1873b4f1d6c6b49464e2c6#body_text
is schema:about of	named entity 'IMMUNOFLUORESCENCE ASSAYS' named entity 'DUE TO' named entity 'ALPHAVIRUSES' named entity 'DIFFERENT' named entity 'NON-' named entity 'HOST FACTOR' named entity 'CHEMICAL' named entity 'UNAVAILABILITY' named entity 'ROLES' named entity 'COMPARTMENT' named entity 'FOCI' named entity 'SEMLIKI FOREST VIRUS' named entity 'TRAFFICKING' named entity 'FAMILIES' named entity 'VIRUS' named entity 'STRUCTURAL' named entity 'CONFIRMED' named entity 'REPLICATION' named entity 'SIRNA' named entity 'VCP' named entity 'REPLICATION' named entity 'BUT' named entity 'INCLUDING' named entity 'IS A' named entity 'USING' named entity 'PROTEINS' named entity 'ALPHAVIRUSES' named entity 'INVOLVED' named entity 'HUMAN CELL LINES' named entity 'FLAVIVIRIDAE' named entity 'HERE' named entity 'TRANS' named entity 'PROTEIN ' named entity 'ROLE' named entity 'CONSERVED' named entity 'HERPESVIRIDAE' named entity 'LOCALIZED' named entity 'NOT EVALUATED' named entity 'CHIKUNGUNYA VIRUS' named entity 'FACTOR' named entity 'PRO-' named entity 'FUNCTIONS' named entity 'EXTEND' named entity 'SINDBIS VIRUS' named entity 'POSSIBLY' named entity 'PREVIOUSLY' named entity 'VALOSIN-CONTAINING PROTEIN' named entity 'AAA' named entity 'AFFECT' named entity 'VIRAL' named entity 'DSRNA' named entity 'INHIBITORS' named entity 'REPLICASE' named entity 'OBSERVED' named entity 'ATPASE' named entity 'EPITOPE' named entity 'BIOLOGY' named entity 'CELLULAR' named entity 'VIRUS RECEPTOR' named entity 'PICORNAVIRIDAE' named entity 'CHIKUNGUNYA VIRUS' named entity 'HOST FACTOR' named entity 'IS A' named entity 'VIRUSES' named entity 'COMPONENT' named entity 'SFV' named entity 'VIRUS-HOST INTERACTION' covid:arg/8778a5efe2618f5d7c1873b4f1d6c6b49464e2c6 named entity 'VCP' named entity 'SFV' named entity 'AAA+ ATPase' named entity 'Semliki Forest'

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