About: Epidemiology of Parkinson's disease

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Epidemiology of Parkinson's disease
Creator	Chade, Annabel Kasten, Meike Tanner, Caroline
source	Elsevier; Medline; PMC
abstract	Publisher Summary This chapter discusses the epidemiology of Parkinson's disease (PD). Classically, PD refers to progressive parkinsonism caused by loss of pigmented aminergic brainstem neurons without an identifiable cause, while parkinsonism refers simply to the syndrome of bradykinesia, resting tremor, rigidity and postural reflex impairment. Over nearly two centuries, Parkinson's clinical description has provided the framework for clinical investigations, including epidemiologic ones. Descriptions of PD were limited to selected clinical settings until the middle of the 20th century. Since then, epidemiologic approaches have been used not only to investigate the population distribution of PD, but also as a way to glean clues as to the cause of this “idiopathic” disorder. Because PD is relatively infrequent, a large base population must be surveyed to identify sufficient numbers of cases for a study. In some instances, PD cases can be identified through health service rosters within defined geographic areas or in enumerated populations. In others, cases of PD are sought independently of the health care system, such as through door-to-door surveys. While the latter approach is theoretically least likely to exclude cases, the time and cost involved are also greatest using this approach.
has issue date	2007-12-31(xsd:dateTime)
bibo:doi	10.1016/s0072-9752(07)83006-5
bibo:pmid	18808913
has license	els-covid
sha1sum (hex)	87888574eed904f7328cf95266c4c09939333c2a
schema:url	https://doi.org/10.1016/s0072-9752%2807%2983006-5
resource representing a document's title	Epidemiology of Parkinson's disease
has PubMed Central identifier	PMC7112363
has PubMed identifier	18808913
schema:publication	Handbook of Clinical Neurology
resource representing a document's body	covid:87888574eed904f7328cf95266c4c09939333c2a#body_text
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