About: Maternal and neonatal outcomes associated with COVID-19 infection: A systematic review

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Maternal and neonatal outcomes associated with COVID-19 infection: A systematic review
Creator	Chin, Ken Ofori-Asenso, Richard Da Silva Costa, Fabricio Krishnan, Sathya Payne, Olivia Salih, Mohamed Seoid, Densearn Smithid, Vinayak Vollenhoven, Beverley Wallace, Euan Warty, Ritesh
source	Medline; PMC
abstract	BACKGROUND: COVID-19 has created an extraordinary global health crisis. However, with limited understanding of the effects of COVID-19 during pregnancy, clinicians and patients are forced to make uninformed decisions. OBJECTIVES: To systematically evaluate the literature and report the maternal and neonatal outcomes associated with COVID-19. SEARCH STRATEGY: PubMed, MEDLINE, and EMBASE were searched from November 1(st), 2019 and March 28(th), 2020. SELECTION CRITERIA: Primary studies, reported in English, investigating COVID-19-positive pregnant women and reporting their pregnancy and neonatal outcomes. DATA COLLECTION AND ANALYSIS: Data in relation to clinical presentation, investigation were maternal and neonatal outcomes were extracted and analysed using summary statistics. Hypothesis testing was performed to examine differences in time-to-delivery. Study quality was assessed using the ICROMS tool. MAIN RESULTS: Of 73 identified articles, nine were eligible for inclusion (n = 92). 67.4% (62/92) of women were symptomatic at presentation. RT-PCR was inferior to CT-based diagnosis in 31.7% (26/79) of cases. Maternal mortality rate was 0% and only one patient required intensive care and ventilation. 63.8% (30/47) had preterm births, 61.1% (11/18) fetal distress and 80% (40/50) a Caesarean section. 76.92% (11/13) of neonates required NICU admission and 42.8% (40/50) had a low birth weight. There was one indeterminate case of potential vertical transmission. Mean time-to-delivery was 4.3±3.08 days (n = 12) with no difference in outcomes (p>0.05). CONCLUSIONS: COVID-19-positive pregnant women present with fewer symptoms than the general population and may be RT-PCR negative despite having signs of viral pneumonia. The incidence of preterm births, low birth weight, C-section, NICU admission appear higher than the general population.
has issue date	2020-06-04(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0234187
bibo:pmid	32497090
has license	cc-by
sha1sum (hex)	8788db8fd43d58fcab98c7420c5f2e4840b2aad7
schema:url	https://doi.org/10.1371/journal.pone.0234187
resource representing a document's title	Maternal and neonatal outcomes associated with COVID-19 infection: A systematic review
has PubMed Central identifier	PMC7272020
has PubMed identifier	32497090
schema:publication	PLoS One
resource representing a document's body	covid:8788db8fd43d58fcab98c7420c5f2e4840b2aad7#body_text
is schema:about of	named entity 'neonatal' named entity 'Wuhan' named entity 'maternal morbidity and mortality' named entity 'mortality rates' named entity 'antenatal' named entity 'SARS' named entity 'Systematic review' named entity 'hypothesis testing' named entity 'stillbirth' named entity 'vertical transmission' named entity '36 hours' named entity 'pneumonia' named entity 'serological' named entity 'COVID-19 testing' named entity 'neonatal mortality' named entity 'China' named entity 'Meta-analysis' named entity 'non-pregnant' named entity 'China' named entity 'coronaviridae' named entity 'dyspneic' named entity 'pregnancy' named entity 'SARS' named entity 'fever' named entity 'fetal' named entity 'RT-PCR' named entity 'dyspnoea' named entity 'COVID' named entity 'iatrogenic' named entity 'pregnancy' named entity 'pregnancy' named entity 'neonatal death' named entity 'Systematic review' named entity 'physiological' named entity 'sample size' named entity 'RT-PCR' named entity 'false negatives' named entity 'China' named entity 'epidemics' named entity 'Preterm delivery' named entity 'statistical significance' named entity 'SPSS' named entity 'SARS' named entity 'preterm delivery' named entity 'vaginal delivery' named entity 'afebrile' named entity 'fetus' named entity 'COVID' named entity 'public health' named entity 'infection' named entity 'clinical phenotype' named entity 'symptom' named entity 'COVID' named entity 'mechanical ventilation' named entity 'LBW' named entity 'MERS-CoV' named entity 'neonates' named entity '3, 4' named entity 'hypoxia' named entity 'coronaviruses' named entity 'neonates' named entity 'respiratory failure' named entity 'pneumonia' named entity 'multidisciplinary approach' named entity 'COVID' named entity 'SARS-CoV-2 virus' named entity 'viruses' named entity 'caesarean' named entity 'LBW' named entity 'viral pneumonia' named entity 'SARS'

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