About: Assessment of PaO(2)/FiO(2) for stratification of patients with moderate and severe acute respiratory distress syndrome

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About: Assessment of PaO(2)/FiO(2) for stratification of patients with moderate and severe acute respiratory distress syndrome Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Assessment of PaO(2)/FiO(2) for stratification of patients with moderate and severe acute respiratory distress syndrome
Creator	Andaluz-Ojeda, David Blanco, Jesús González-Higueras, Elena Villar, Jesús Blanch, Lluis Córcoles, Virgilio López, Julia Muriel, Arturo Pérez-Méndez, Lina Suárez-Sipmann, Fernando Tarancón, Concepción Kacmarek, Robert Díaz-Domínguez, Francisco Fernández, Rosa Del Campo, Rafael
Source	Medline; PMC
abstract	OBJECTIVES: A recent update of the definition of acute respiratory distress syndrome (ARDS) proposed an empirical classification based on ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PaO(2)/FiO(2)) at ARDS onset. Since the proposal did not mandate PaO(2)/FiO(2) calculation under standardised ventilator settings (SVS), we hypothesised that a stratification based on baseline PaO(2)/FiO(2) would not provide accurate assessment of lung injury severity. DESIGN: A prospective, multicentre, observational study. SETTING: A network of teaching hospitals. PARTICIPANTS: 478 patients with eligible criteria for moderate (100<PaO(2)/FiO(2)≤200) and severe (PaO(2)/FiO(2)≤100) ARDS and followed until hospital discharge. INTERVENTIONS: We examined physiological and ventilator parameters in association with the PaO(2)/FiO(2) at ARDS onset, after 24 h of usual care and at 24 h under a SVS. At 24 h, patients were reclassified as severe, moderate, mild (200<PaO(2)/FiO(2)≤300) ARDS and non-ARDS (PaO(2)/FiO(2)>300). PRIMARY AND SECONDARY OUTCOMES: Group severity and hospital mortality. RESULTS: At ARDS onset, 173 patients had a PaO(2)/FiO(2)≤100 but only 38.7% met criteria for severe ARDS at 24 h under SVS. When assessed under SVS, 61.3% of patients with severe ARDS were reclassified as moderate, mild and non-ARDS, while lung severity and hospital mortality changed markedly with every PaO(2)/FiO(2) category (p<0.000001). Our model of risk stratification outperformed the stratification using baseline PaO(2)/FiO(2) and non-standardised PaO(2)/FiO(2) at 24 h, when analysed by the predictive receiver operating characteristic (ROC) curve: area under the ROC curve for stratification at baseline was 0.583 (95% CI 0.525 to 0.636), 0.605 (95% CI 0.552 to 0.658) at 24 h without SVS and 0.693 (95% CI 0.645 to 0.742) at 24 h under SVS (p<0.000001). CONCLUSIONS: Our findings support the need for patient assessment under SVS at 24 h after ARDS onset to assess disease severity, and have implications for the diagnosis and management of ARDS patients. TRIAL REGISTRATION NUMBERS: NCT00435110 and NCT00736892.
has issue date	2015-03-27(xsd:dateTime)
bibo:doi	10.1136/bmjopen-2014-006812
bibo:pmid	25818272
has license	cc-by-nc
sha1sum (hex)	8793343683237029bac548225ba51f403489cd35
schema:url	https://doi.org/10.1136/bmjopen-2014-006812
resource representing a document's title	Assessment of PaO(2)/FiO(2) for stratification of patients with moderate and severe acute respiratory distress syndrome
has PubMed Central identifier	PMC4386240
has PubMed identifier	25818272
schema:publication	BMJ Open
resource representing a document's body	covid:8793343683237029bac548225ba51f403489cd35#body_text
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