About: Genome-Wide Transcriptional Profiling Reveals Two Distinct Outcomes in Central Nervous System Infections of Rabies Virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genome-Wide Transcriptional Profiling Reveals Two Distinct Outcomes in Central Nervous System Infections of Rabies Virus
Creator	Wu, Fan Fan, Huiying Chen, Jinding Bi, Shuilian Guo, Huixia Guo, Xiaofeng He, Feilong Ju, Chunmei Liang, Jiaqi Luo, Yongwen Tian, Qin Yang, Youtian Zhang, Baoshi Zhang, Daiting Iha, Hidekatsu Akari, Hirofumi Liang, Wu Morikawa, Kenichi
topic	covid:87b2f2205b9dea38eeaeddd6e3ddbb6e45f542ae#this
Source	Medline; PMC
abstract	Rabies remains a major public health concern in many developing countries. The precise neuropathogenesis of rabies is unknown, though it is hypothesized to be due to neuronal death or dysfunction. Mice that received intranasal inoculation of an attenuated rabies virus (RABV) strain HEP-Flury exhibited subtle clinical signs, and eventually recovered, which is different from the fatal encephalitis caused by the virulent RABV strain CVS-11. To understand the neuropathogenesis of rabies and the mechanisms of viral clearance, we applied RNA sequencing (RNA-Seq) to compare the brain transcriptomes of normal mice vs. HEP-Flury or CVS-11 intranasally inoculated mice. Our results revealed that both RABV strains altered positively and negatively the expression levels of many host genes, including genes associated with innate and adaptive immunity, inflammation and cell death. It is found that HEP-Flury infection can activate the innate immunity earlier through the RIG-I/MDA-5 signaling, and the innate immunity pre-activated by HEP-Flury or Newcastle disease virus (NDV) infection can effectively prevent the CVS-11 to invade central nervous system (CNS), but fails to clear the CVS-11 after its entry into the CNS. In addition, following CVS-11 infection, genes implicated in cell adhesion, blood vessel morphogenesis and coagulation were mainly up-regulated, while the genes involved in synaptic transmission and ion transport were significantly down-regulated. On the other hand, several genes involved in the MHC class II-mediated antigen presentation pathway were activated to a greater extent after the HEP-Flury infection as compared with the CVS-11 infection suggesting that the collaboration of CD4(+) T cells and MHC class II-mediated antigen presentation is critical for the clearance of attenuated RABV from the CNS. The differentially regulated genes reported here are likely to include potential therapeutic targets for expanding the post-exposure treatment window for RABV infection.
has issue date	2016-05-19(xsd:dateTime)
bibo:doi	10.3389/fmicb.2016.00751
bibo:pmid	27242764
has license	cc-by
sha1sum (hex)	87b2f2205b9dea38eeaeddd6e3ddbb6e45f542ae
schema:url	https://doi.org/10.3389/fmicb.2016.00751
resource representing a document's title	Genome-Wide Transcriptional Profiling Reveals Two Distinct Outcomes in Central Nervous System Infections of Rabies Virus
has PubMed Central identifier	PMC4871871
has PubMed identifier	27242764
schema:publication	Front Microbiol
resource representing a document's body	covid:87b2f2205b9dea38eeaeddd6e3ddbb6e45f542ae#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/87b2f2205b9dea38eeaeddd6e3ddbb6e45f542ae
is schema:about of	named entity 'REPORTED' named entity 'INFLAMMATION' named entity 'THERAPEUTIC' named entity 'INCLUDE' named entity 'WINDOW' named entity 'CD4' named entity 'BUT' named entity 'FAILS' named entity 'BLOOD VESSEL MORPHOGENESIS' named entity 'INVOLVED' named entity 'RECEIVED' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'PREVENT' named entity 'HOST' named entity 'REGULATED' named entity 'FOUND' named entity 'ANTIGEN PRESENTATION PATHWAY' named entity 'PRE' named entity 'CELL DEATH' named entity 'RABIES' named entity 'UNDERSTAND' named entity 'UP-REGULATED' named entity 'GENES' named entity 'DYSFUNCTION' named entity 'RABIES VIRUS' named entity 'INTRANASAL INOCULATION' named entity 'VIRAL CLEARANCE' named entity 'COMPARED' named entity 'REVEALED' named entity 'APPLIED' named entity 'COAGULATION' named entity 'RESULTS' named entity 'POSITIVELY AND NEGATIVELY' named entity 'HERE' named entity 'CNS' named entity 'LEVELS' named entity 'VIRULENT' named entity 'FATAL' named entity 'invade' named entity 'immunity' named entity 'infection' named entity 'expanding' named entity 'levels' named entity 'virus' named entity 'neuronal death' named entity 'mice' named entity 'cell death' named entity 'infection' named entity 'involved' named entity 'infection' named entity 'regulated' named entity 'blood vessel' named entity 'genes' named entity 'TREATMENT' named entity 'ENCEPHALITIS' named entity 'ADDITION' named entity 'ACTIVATE' named entity 'MHC CLASS II' named entity 'INVADE' named entity 'OUR' named entity 'EXTENT' named entity 'SYNAPTIC TRANSMISSION'

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