About: Vacuolating encephalitis in mice infected by human coronavirus OC43

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Vacuolating encephalitis in mice infected by human coronavirus OC43
Creator	Jacomy, Hélène Talbot, Pierre
Source	Elsevier; Medline; PMC
abstract	Abstract Involvement of viruses in human neurodegenerative diseases and the underlying pathologic mechanisms remain generally unclear. Human respiratory coronaviruses (HCoV) can infect neural cells, persist in human brain, and activate myelin-reactive T cells. As a means of understanding the human infection, we characterized in vivo the neurotropic and neuroinvasive properties of HCoV-OC43 through the development of an experimental animal model. Virus inoculation of 21-day postnatal C57BL/6 and BALB/c mice led to a generalized infection of the whole CNS, demonstrating HCoV-OC43 neuroinvasiveness and neurovirulence. This acute infection targeted neurons, which underwent vacuolation and degeneration while infected regions presented strong microglial reactivity and inflammatory reactions. Damage to the CNS was not immunologically mediated and microglial reactivity was instead a consequence of direct virus-mediated neuronal injury. Although this acute encephalitis appears generally similar to that induced by murine coronaviruses, an important difference rests in the prominent spongiform-like degeneration that could trigger neuropathology in surviving animals.
has issue date	2003-10-10(xsd:dateTime)
bibo:doi	10.1016/s0042-6822(03)00323-4
bibo:pmid	14592756
has license	els-covid
sha1sum (hex)	87b6a8ab446e5be0bb9e07f85c43ce6c0203de3e
schema:url	https://doi.org/10.1016/s0042-6822%2803%2900323-4
resource representing a document's title	Vacuolating encephalitis in mice infected by human coronavirus OC43
has PubMed Central identifier	PMC7126296
has PubMed identifier	14592756
schema:publication	Virology
resource representing a document's body	covid:87b6a8ab446e5be0bb9e07f85c43ce6c0203de3e#body_text
is schema:about of	named entity 'activate' named entity 'encephalitis' named entity 'day' named entity 'rests' named entity 'CNS' named entity 'animals' named entity 'coronavirus' named entity 'REACTIVE' named entity 'MICROGLIAL' named entity 'CELLS' named entity 'INFECTED' named entity 'MEDIATED' named entity 'PRESENTED' named entity 'GENERALLY' named entity 'INOCULATION' named entity 'REACTIVITY' named entity 'MURINE' named entity 'VIRUSES' named entity 'DEVELOPMENT' named entity 'POSTNATAL' named entity 'INFECT' named entity 'NEUROINVASIVENESS' named entity 'C57BL' named entity 'RESTS' named entity 'UNCLEAR' named entity 'CHARACTERIZED' named entity 'ACTIVATE' named entity 'UNDERSTANDING' named entity 'STRONG' named entity 'MECHANISMS' named entity 'INDUCED' named entity 'IMPORTANT' named entity 'MYELIN' named entity 'INFECTION' named entity 'PATHOLOGIC' named entity 'INFLAMMATORY REACTIONS' named entity 'TRIGGER' named entity 'REGIONS' named entity 'CNS' named entity 'MEANS' named entity 'VACUOLATION' named entity 'HUMAN CORONAVIRUS OC43' named entity 'MICE' named entity 'DAMAGE' named entity 'BRAIN' named entity 'GENERALIZED INFECTION' named entity 'BALB' named entity 'UNDERLYING' named entity 'ACUTE INFECTION' named entity 'INVOLVEMENT' named entity 'NEUROPATHOLOGY' named entity 'INJURY' named entity 'SIMILAR' named entity 'RESPIRATORY' named entity 'NEURONS' named entity 'ACUTE ENCEPHALITIS' named entity 'INFECTED' named entity 'ENCEPHALITIS' named entity 'EXPERIMENTAL ANIMAL MODEL' named entity 'NEUROVIRULENCE' named entity 'PROPERTIES' named entity 'NEURAL' named entity 'IN VIVO' named entity 'SPONGIFORM' named entity 'ANIMALS' named entity 'NEURONAL' named entity 'DIRECT' named entity 'MICE' named entity 'CONSEQUENCE OF' named entity 'PROMINENT' named entity 'NEURODEGENERATIVE DISEASES' named entity 'HUMAN' named entity 'DEGENERATION' named entity 'VIRUS' named entity 'DAY' named entity 'TARGETED' named entity 'HCOV-OC43' named entity 'LIKE' named entity 'LED' named entity 'DIFFERENCE'

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