About: Challenges in use of saliva for detection of SARS CoV-2 RNA in symptomatic outpatients

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Challenges in use of saliva for detection of SARS CoV-2 RNA in symptomatic outpatients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Challenges in use of saliva for detection of SARS CoV-2 RNA in symptomatic outpatients
Creator	Landry, Marie Peaper, David Criscuolo, Jody
source	Elsevier; Medline; PMC
abstract	BACKGROUND: A major expansion in SARS CoV-2 testing is urgently needed. Saliva is an attractive option as an alternative for nasopharyngeal swabs (NPS), since saliva can be self-collected, is non-invasive, and sample quality is not dependent on the expertise of the collector. OBJECTIVE: To compare SARS CoV-2 positivity on paired NPS and saliva samples. STUDY DESIGN: NPS and paired saliva samples were prospectively collected from symptomatic outpatients suspected of having COVID-19 and were tested by real-time RT-PCR. RESULTS: In total, 35/124 (26.6 %) samples were RT-PCR positive, with 33/35 positive by NPS (sensitivity = 94.3 % (95 % CI 81.4%–99.0%)) and 30/35 by pure saliva (sensitivity = 85.7 % (95 % CI 70.6%–93.7%)), for an overall agreement of 117/124 (94.4 %). The median cycle threshold value was significantly lower for NPS than for saliva (p = 0.0331). A third or more of pure saliva samples from symptomatic patients were thick, stringy, and difficult to pipet. CONCLUSIONS: Real-time RT-PCR of pure saliva had an overall sensitivity for SARS CoV-2 RNA detection of 85.7 % when compared to simultaneously collected NPS. Our study highlighted the need to optimize collection and processing before saliva can be used for high volume testing.
has issue date	2020-07-31(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2020.104567
bibo:pmid	32750665
has license	no-cc
sha1sum (hex)	87cd35c59d0bebc43a97e10b9ae07839ca4615a3
schema:url	https://doi.org/10.1016/j.jcv.2020.104567
resource representing a document's title	Challenges in use of saliva for detection of SARS CoV-2 RNA in symptomatic outpatients
has PubMed Central identifier	PMC7392849
has PubMed identifier	32750665
schema:publication	J Clin Virol
resource representing a document's body	covid:87cd35c59d0bebc43a97e10b9ae07839ca4615a3#body_text
is schema:about of	named entity 'https' named entity 'Jody' named entity 'detection' named entity 'Data curation' named entity 'Writing' named entity 'RNA' covid:arg/87cd35c59d0bebc43a97e10b9ae07839ca4615a3 named entity 'RNA' named entity 'outpatients' named entity 'RNA' named entity 'saliva' named entity 'Supervision' named entity 'SARS CoV' named entity 'SARS CoV' named entity 'RNA' named entity 'original draft' named entity 'Data curation' named entity 'sneezing' named entity 'saliva' named entity 'Thermo Scientific' named entity 'saliva' named entity 'VTM' named entity 'saliva' named entity 'saliva' named entity 'saliva' named entity 'PCR' named entity 'coughing' named entity 'clinical laboratory' named entity 'saliva' named entity 'medical procedures' named entity 'SARS CoV' named entity 'Yale New Haven Hospital' named entity 'inoculation' named entity 'saliva' named entity 'SARS CoV' named entity 'saliva' named entity 'Becton Dickinson' named entity 'non-viscous' named entity 'Saliva' named entity 'pipette' named entity 'saliva' named entity 'Hong Kong' named entity 'saliva' named entity 'saliva' named entity 'Saliva' named entity 'saliva' named entity 'Sunnyvale' named entity 'SARS CoV' named entity 'PCR' named entity 'GeneXpert' named entity 'RNA' named entity 'saliva' named entity 'residential college' named entity 'healthcare workers' named entity '1/50' named entity 'saliva' named entity 'personal protective equipment (PPE' named entity 'RNA' named entity 'saliva' named entity 'asymptomatic' named entity 'RNA' named entity 'PCR' named entity 'saliva' named entity 'volume testing' named entity 'saliva' named entity 'saliva' named entity 'Reverse-transcriptase' named entity 'saliva' named entity 'Infectious Diseases Society of America' named entity 'SARS-CoV-2' named entity 'saliva' named entity 'SARS-CoV-2' named entity 'asymptomatic' named entity 'asymptomatic' named entity 'viscous' named entity 'bioMerieux' named entity 'RT-PCR' named entity 'SARS CoV' named entity 'PCR'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software