About: RIG-I in RNA virus recognition

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About: RIG-I in RNA virus recognition Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	RIG-I in RNA virus recognition
Creator	Gale, Michael Kell, Alison
Source	Elsevier; Medline; PMC
abstract	Abstract Antiviral immunity is initiated upon host recognition of viral products via non-self molecular patterns known as pathogen-associated molecular patterns (PAMPs). Such recognition initiates signaling cascades that induce intracellular innate immune defenses and an inflammatory response that facilitates development of the acquired immune response. The retinoic acid-inducible gene I (RIG-I) and the RIG-I-like receptor (RLR) protein family are key cytoplasmic pathogen recognition receptors that are implicated in the recognition of viruses across genera and virus families, including functioning as major sensors of RNA viruses, and promoting recognition of some DNA viruses. RIG-I, the charter member of the RLR family, is activated upon binding to PAMP RNA. Activated RIG-I signals by interacting with the adapter protein MAVS leading to a signaling cascade that activates the transcription factors IRF3 and NF-κB. These actions induce the expression of antiviral gene products and the production of type I and III interferons that lead to an antiviral state in the infected cell and surrounding tissue. RIG-I signaling is essential for the control of infection by many RNA viruses. Recently, RIG-I crosstalk with other pathogen recognition receptors and components of the inflammasome has been described. In this review, we discuss the current knowledge regarding the role of RIG-I in recognition of a variety of virus families and its role in programming the adaptive immune response through cross-talk with parallel arms of the innate immune system, including how RIG-I can be leveraged for antiviral therapy.
has issue date	2015-05-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2015.02.017
bibo:pmid	25749629
has license	els-covid
sha1sum (hex)	87f87fc7c57a174d321ecf36ffa85ef323c04f7f
schema:url	https://doi.org/10.1016/j.virol.2015.02.017
resource representing a document's title	RIG-I in RNA virus recognition
has PubMed Central identifier	PMC4424084
has PubMed identifier	25749629
schema:publication	Virology
resource representing a document's body	covid:87f87fc7c57a174d321ecf36ffa85ef323c04f7f#body_text
is schema:about of	named entity 'RNA virus' named entity 'RIG-I' named entity 'RNA VIRUS' named entity 'RECOGNITION' named entity 'double-stranded' named entity 'ligand' named entity 'cell surface' named entity 'RNA' named entity 'caspase-10' named entity 'RIG-I' named entity 'virus infection' named entity 'endosomal' named entity 'RIG-I' named entity 'PAMPs' named entity 'cytoplasmic' named entity 'RIG-I' named entity 'signaling cascades' named entity 'RNA viruses' named entity 'RIG-I' named entity 'PAMPs' named entity 'adjuvant' named entity 'inflammasome' named entity 'NS1' named entity 'respiratory distress' named entity 'evolution' named entity 'EBOV' named entity 'agonists' named entity 'MDA5' named entity 'crosstalk' named entity 'case-fatality ratios' named entity 'protein synthesis' named entity 'MDA5' named entity 'host defenses' named entity 'RIG-I' named entity 'RLR' named entity 'nairovirus' named entity 'STAT2' named entity 'SINV' named entity 'death domain' named entity 'cell lines' named entity 'single stranded RNA' named entity 'RIG-I' named entity 'enzootic' named entity 'Negative-sense' named entity 'HCV' named entity 'helicase' named entity 'innate immune signaling' named entity 'RIG-I' named entity 'TLR3' named entity 'RIG-I' named entity 'dsRNA' named entity 'RIG-I' named entity 'viruses' named entity 'PAMP' named entity 'uridine' named entity 'PAMP' named entity 'virus infection' named entity 'RNA' named entity 'infection' named entity 'hantaviruses' named entity 'C-type lectin receptors' named entity 'MDA5' named entity 'dsRNA' named entity 'signaling pathway' named entity 'flaviviruses' named entity 'infection' named entity 'TBK1' named entity 'infection' named entity 'RNA' named entity 'innate immune response' named entity 'RIG-I' named entity 'infection' named entity 'RLR' named entity 'RIG-I' named entity 'RIG-I' named entity 'blood products' named entity 'negative-sense, single-stranded' named entity 'selective pressure' named entity 'RIG-I' named entity 'RIG-I'

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