About: Distinguishing patients with laboratory-confirmed chikungunya from dengue and other acute febrile illnesses, Puerto Rico, 2012

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About: Distinguishing patients with laboratory-confirmed chikungunya from dengue and other acute febrile illnesses, Puerto Rico, 2012–2015 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Distinguishing patients with laboratory-confirmed chikungunya from dengue and other acute febrile illnesses, Puerto Rico, 2012–2015
Creator	Hunsperger, Elizabeth Sharp, Tyler Glass Elrod, Mindy Henderson, Elizabeth Horiuchi, Kalanthe Kato, Cecilia Muns-Sosa, Robert Rivera, Aidsa Santiago-Rivera, William Singleton, Joseph Galloway, Renee Lorenzi, Olga Mathis, Demetrius Nix, W Ortiz-Rivera, Juan Tomashek, Kay Mcquiston, Jennifer García-Gubern, Carlos Rivera-Amill, Vanessa Alvarado Id, Luisa Andú Jar-Pé Rez, Doris Gonzá Lez-Zeno, Gladys Id, Oberste Jimé Nez, Gerson Muñoz-Jordá N, Jorge Pé Rez-Padilla, Janice Steven, M Torres-Velá Squez, Brenda Vargas Id, Luzeida
Source	Medline; PMC
abstract	Chikungunya, a mosquito-borne viral, acute febrile illness (AFI) is associated with polyarthralgia and polyarthritis. Differentiation from other AFI is difficult due to the non-specific presentation and limited availability of diagnostics. This 3-year study identified independent clinical predictors by day post-illness onset (DPO) at presentation and age-group that distinguish chikungunya cases from two groups: other AFI and dengue. Specimens collected from participants with fever ≤7 days were tested for chikungunya, dengue viruses 1–4, and 20 other pathogens. Of 8,996 participants, 18.2% had chikungunya, and 10.8% had dengue. Chikungunya cases were more likely than other groups to be older, report a chronic condition, and present <3 DPO. Regardless of timing of presentation, significant positive predictors for chikungunya versus other AFI were: joint pain, muscle, bone or back pain, skin rash, and red conjunctiva; with dengue as the comparator, red swollen joints (arthritis), joint pain, skin rash, any bleeding, and irritability were predictors. Chikungunya cases were less likely than AFI and dengue to present with thrombocytopenia, signs of poor circulation, diarrhea, headache, and cough. Among participants presenting <3 DPO, predictors for chikungunya versus other AFI included: joint pain, skin rash, and muscle, bone or back pain, and absence of thrombocytopenia, poor circulation and respiratory or gastrointestinal symptoms; when the comparator was dengue, joint pain and arthritis, and absence of thrombocytopenia, leukopenia, and nausea were early predictors. Among all groups presenting 3–5 DPO, pruritic skin became a predictor for chikungunya, joint, muscle, bone or back pain were no longer predictive, while arthritis became predictive in all age-groups. Absence of thrombocytopenia was a significant predictor regardless of DPO or comparison group. This study identified robust clinical indicators such as joint pain, skin rash and absence of thrombocytopenia that can allow early identification of and accurate differentiation between patients with chikungunya and other common causes of AFI.
has issue date	2019-07-22(xsd:dateTime)
bibo:doi	10.1371/journal.pntd.0007562
bibo:pmid	31329598
has license	cc0
sha1sum (hex)	87fc63465850255babe819a7292d33fa2f597609
schema:url	https://doi.org/10.1371/journal.pntd.0007562
resource representing a document's title	Distinguishing patients with laboratory-confirmed chikungunya from dengue and other acute febrile illnesses, Puerto Rico, 2012–2015
has PubMed Central identifier	PMC6645456
has PubMed identifier	31329598
schema:publication	PLoS Negl Trop Dis
resource representing a document's body	covid:87fc63465850255babe819a7292d33fa2f597609#body_text
is schema:about of	named entity 'muscle' named entity 'bone' named entity 'comparator' named entity 'early' named entity 'polyarthralgia' named entity '7 days' named entity 'chikungunya' named entity 'study design' named entity 'illnesses' named entity 'laboratory' named entity 'HTTPS' named entity 'ACUTE FEBRILE ILLNESS' named entity 'COMMON' named entity 'GROUPS' named entity 'WAS A' named entity 'Differentiation' named entity 'cough' named entity 'dengue' named entity 'thrombocytopenia' named entity 'thrombocytopenia' named entity 'conjunctiva' named entity 'arthritis' named entity 'skin rash' named entity 'Diseases' named entity 'bone' named entity 'identified' named entity 'skin' named entity 'DPO' named entity 'This' named entity 'DPO' named entity 'respiratory' named entity 'dengue' named entity 'comparison group' named entity 'joint pain' named entity 'polyarthritis' named entity 'viruses' named entity 'conjunctiva' named entity 'thrombocytopenia' named entity 'cough' named entity 'nausea' named entity 'doi' named entity 'chikungunya' named entity 'non-specific' named entity 'chikungunya' named entity 'chikungunya' named entity 'thrombocytopenia' named entity 'chikungunya' named entity 'thrombocytopenia' named entity 'chikungunya' named entity 'febrile' named entity 'multivariate analyses' named entity 'conjunctiva' named entity 'lower extremity'

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