About: Characterization of a New Pathogenic Acanthamoeba Species, A. byersi n. sp., Isolated from a Human with Fatal Amoebic Encephalitis

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About: Characterization of a New Pathogenic Acanthamoeba Species, A. byersi n. sp., Isolated from a Human with Fatal Amoebic Encephalitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of a New Pathogenic Acanthamoeba Species, A. byersi n. sp., Isolated from a Human with Fatal Amoebic Encephalitis
Creator	Nerad, Thomas Qvarnstrom, Yvonne Govinda, & Visvesvara, S
Source	PMC
abstract	Acanthamoeba spp. are free‐living amoebae that are ubiquitous in natural environments. They can cause cutaneous, nasopharyngeal, and disseminated infection, leading to granulomatous amebic encephalitis (GAE) in immunocompromised individuals. In addition, they can cause amoebic keratitis in contact lens wearers. Acanthamoeba GAE is almost always fatal because of difficulty and delay in diagnosis and lack of optimal antimicrobial therapy. Here, we report the description of an unusual strain isolated from skin and brain of a GAE patient. The amoebae displayed large trophozoites and star‐shaped cysts, characteristics for acanthamoebas belonging to morphology Group 1. However, its unique morphology and growth characteristics differentiated this new strain from other Group 1 species. DNA sequence analysis, secondary structure prediction, and phylogenetic analysis of the 18S rRNA gene confirmed that this new strain belonged to Group 1, but that it was distinct from the other sequence types within that group. Thus, we hereby propose the establishment of a new species, Acanthamoeba byersi n. sp. as well as a new sequence type, T18, for this new strain. To our knowledge, this is the first report of a Group 1 Acanthamoeba that is indisputably pathogenic in humans.
has issue date	2013-07-24(xsd:dateTime)
bibo:doi	10.1111/jeu.12069
bibo:pmid	23879685
has license	no-cc
sha1sum (hex)	87ffa2b27b6bb449e18229ab32118faab2a26eaa
schema:url	https://doi.org/10.1111/jeu.12069
resource representing a document's title	Characterization of a New Pathogenic Acanthamoeba Species, A. byersi n. sp., Isolated from a Human with Fatal Amoebic Encephalitis
has PubMed Central identifier	PMC4618466
has PubMed identifier	23879685
schema:publication	J Eukaryot Microbiol
resource representing a document's body	covid:87ffa2b27b6bb449e18229ab32118faab2a26eaa#body_text
is schema:about of	named entity 'Acanthamoeba' named entity 'phylogenetic analysis' named entity 'individuals' named entity 'differentiated' named entity 'brain' named entity 'Human' named entity 'Characterization' named entity 'leading' named entity 'skin' named entity 'type' named entity 'humans' named entity 'unique' named entity 'morphologic' named entity 'Acanthamoeba castellanii' named entity 'distilled water' named entity 'encyst' named entity 'CDC' named entity 'nucleotides' named entity 'Acanthamoeba' named entity 'Species' named entity 'cutaneous' named entity 'Acanthamoeba' named entity 'infection' named entity '18S rRNA gene' named entity 'antimicrobial therapy' named entity 'belonging' named entity 'nucleated cells' named entity 'Acanthamoeba' named entity '18S rRNA gene' named entity 'Phylogenetic analysis' named entity 'clones' named entity 'amoebae' named entity 'particles in the air' named entity 'antibody' named entity 'free-living' named entity 'cysts' named entity 'meningoencephalitis' named entity 'lesion' named entity 'Acanthamoeba' named entity 'CDC' named entity 'eye trauma' named entity 'encephalitis' named entity 'human lung' named entity 'CNS' named entity 'Life Technologies' named entity 'amoeba' named entity 'Acanthamoeba' named entity 'trophozoites' named entity '18S rRNA gene' named entity 'DNA sequencing' named entity 'punch biopsy' named entity 'Gram-negative bacterium' named entity 'heterogeneity' named entity 'trophozoites' named entity 'Valencia, CA' named entity 'CNS' named entity 'CDC' named entity 'electron microscopy' named entity '18S rRNA' named entity 'karyokinesis' named entity 'Acanthamoeba' named entity 'agarose' named entity '18S rRNA gene' named entity 'clade' named entity 'secondary structure prediction' named entity 'QIAGEN' named entity 'Acanthamoeba' named entity 'fetal bovine serum' named entity 'insertions/deletions' named entity '30°C' named entity 'axenic' named entity 'base pairs' named entity 'gene' named entity 'cysts' named entity 'cyst' named entity 'morphologic' named entity 'ribosomal RNA' named entity 'CPEs'

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