About: Sensitivity of Model-Based Epidemiological Parameter Estimation to Model Assumptions

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Sensitivity of Model-Based Epidemiological Parameter Estimation to Model Assumptions
Creator	Lloyd, A
Source	PMC
abstract	Estimation of epidemiological parameters from disease outbreak data often proceeds by fitting a mathematical model to the data set. The resulting parameter estimates are subject to uncertainty that arises from errors (noise) in the data; standard statistical techniques can be used to estimate the magnitude of this uncertainty. The estimates are also dependent on the structure of the model used in the fitting process and so any uncertainty regarding this structure leads to additional uncertainty in the parameter estimates. We argue that if we lack detailed knowledge of the biology of the transmission process, parameter estimation should be accompanied by a structural sensitivity analysis, in addition to the standard statistical uncertainty analysis. Here we focus on the estimation of the basic reproductive number from the initial growth rate of an outbreak as this is a setting in which parameter estimation can be surprisingly sensitive to details of the time course of infection.
has issue date	2009-01-01(xsd:dateTime)
bibo:doi	10.1007/978-90-481-2313-1_6
has license	no-cc
sha1sum (hex)	8890417f38889a9f57e00bd8e3b687cb1837be9a
schema:url	https://doi.org/10.1007/978-90-481-2313-1_6
resource representing a document's title	Sensitivity of Model-Based Epidemiological Parameter Estimation to Model Assumptions
has PubMed Central identifier	PMC7121564
schema:publication	Mathematical and Statistical Estimation Approaches in Epidemiology
resource representing a document's body	covid:8890417f38889a9f57e00bd8e3b687cb1837be9a#body_text
is schema:about of	named entity 'EPIDEMIOLOGICAL' named entity 'PARAMETER' named entity 'RESULTING' named entity 'ADDITIONAL' named entity 'ANALYSIS' named entity 'LEADS' named entity 'KNOWLEDGE' named entity 'SUBJECT' named entity 'STRUCTURE' named entity 'BIOLOGY' named entity 'DETAILS' named entity 'FOCUS' named entity 'TRANSMISSION PROCESS' named entity 'ADDITION' named entity 'EPIDEMIOLOGICAL' named entity 'SETTING' named entity 'MATHEMATICAL MODEL' named entity 'TIME COURSE' named entity 'ESTIMATE' named entity 'IS A' named entity 'SENSITIVE TO' named entity 'ERRORS' named entity 'STANDARD' named entity 'LACK' named entity 'PROCESS' named entity 'DEPENDENT' named entity 'ESTIMATION' named entity 'MODEL' named entity 'PARAMETER' named entity 'ESTIMATION' named entity 'NUMBER' named entity 'DETAILED' named entity 'TECHNIQUES' named entity 'DISEASE OUTBREAK' named entity 'OUTBREAK' named entity 'MAGNITUDE' named entity 'USED' named entity 'GROWTH RATE' named entity 'STRUCTURAL' named entity 'INFECTION' named entity 'DATA SET' named entity 'ESTIMATES' named entity 'BASED' named entity 'SENSITIVITY' named entity 'BASIC' named entity 'INITIAL' named entity 'HERE' named entity 'UNCERTAINTY' named entity 'DATA' named entity 'REPRODUCTIVE' named entity 'SENSITIVITY ANALYSIS' named entity 'STATISTICAL' named entity 'PARAMETERS' named entity 'FITTING' named entity 'MODEL' covid:arg/8890417f38889a9f57e00bd8e3b687cb1837be9a named entity 'parameter estimates' named entity 'sensitivity analysis' named entity 'statistical techniques' named entity 'parameter estimation' named entity 'Epidemiological' named entity 'Parameter Estimation' named entity 'infection' named entity 'reproductive number' named entity 'positive root' named entity 'reproductive number' named entity 'non-monotonic' named entity 'infection' named entity 'dashed' named entity 'SEIR' named entity 'infection' named entity 'gamma distributed' named entity 'differential equations' named entity 'SIR model' named entity 'SEIR' named entity 'SIR model' named entity 'differential equations' named entity 'infection' named entity 'virus' named entity 'contact tracing' named entity 'SIR model' named entity 'disease outbreak' named entity 'probability'

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