About: Immune and Metabolic Signatures of COVID-19 Revealed by Transcriptomics Data Reuse

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immune and Metabolic Signatures of COVID-19 Revealed by Transcriptomics Data Reuse
Creator	Doolan, Denise Gardinassi, Luiz Fantuzzi, Laura Ashraf, Siddig Fonseca, Simone Sales-Campos, Helioswilton Souza, Camila Yousif,
topic	covid:88b6bf5f42d644dbb591a33e5733b65220ff4b88#this
Source	Medline; PMC
abstract	The current pandemic of coronavirus disease 19 (COVID-19) has affected millions of individuals and caused thousands of deaths worldwide. The pathophysiology of the disease is complex and mostly unknown. Therefore, identifying the molecular mechanisms that promote progression of the disease is critical to overcome this pandemic. To address such issues, recent studies have reported transcriptomic profiles of cells, tissues and fluids from COVID-19 patients that mainly demonstrated activation of humoral immunity, dysregulated type I and III interferon expression, intense innate immune responses and inflammatory signaling. Here, we provide novel perspectives on the pathophysiology of COVID-19 using robust functional approaches to analyze public transcriptome datasets. In addition, we compared the transcriptional signature of COVID-19 patients with individuals infected with SARS-CoV-1 and Influenza A (IAV) viruses. We identified a core transcriptional signature induced by the respiratory viruses in peripheral leukocytes, whereas the absence of significant type I interferon/antiviral responses characterized SARS-CoV-2 infection. We also identified the higher expression of genes involved in metabolic pathways including heme biosynthesis, oxidative phosphorylation and tryptophan metabolism. A BTM-driven meta-analysis of bronchoalveolar lavage fluid (BALF) from COVID-19 patients showed significant enrichment for neutrophils and chemokines, which were also significant in data from lung tissue of one deceased COVID-19 patient. Importantly, our results indicate higher expression of genes related to oxidative phosphorylation both in peripheral mononuclear leukocytes and BALF, suggesting a critical role for mitochondrial activity during SARS-CoV-2 infection. Collectively, these data point for immunopathological features and targets that can be therapeutically exploited to control COVID-19.
has issue date	2020-06-26(xsd:dateTime)
bibo:doi	10.3389/fimmu.2020.01636
bibo:pmid	32670298
has license	cc-by
sha1sum (hex)	88b6bf5f42d644dbb591a33e5733b65220ff4b88
schema:url	https://doi.org/10.3389/fimmu.2020.01636
resource representing a document's title	Immune and Metabolic Signatures of COVID-19 Revealed by Transcriptomics Data Reuse
has PubMed Central identifier	PMC7332781
has PubMed identifier	32670298
schema:publication	Front Immunol
resource representing a document's body	covid:88b6bf5f42d644dbb591a33e5733b65220ff4b88#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/88b6bf5f42d644dbb591a33e5733b65220ff4b88
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