About: Androgen and Androgen Receptors as Regulators of Monocyte and Macrophage Biology in the Healthy and Diseased Lung

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Androgen and Androgen Receptors as Regulators of Monocyte and Macrophage Biology in the Healthy and Diseased Lung
Creator	Bazzoni, Flavia Becerra-Diaz, Mireya Heller, Nicola Parronchi, Paola Song, Mason
Source	Medline; PMC
abstract	Androgens, the predominant male sex hormones, drive the development and maintenance of male characteristics by binding to androgen receptor (AR). As androgens are systemically distributed throughout the whole organism, they affect many tissues and cell types in addition to those in male sexual organs. It is now clear that the immune system is a target of androgen action. In the lungs, many immune cells express ARs and are responsive to androgens. In this review, we describe the effects of androgens and ARs on lung myeloid immune cells—monocytes and macrophages—as they relate to health and disease. In particular, we highlight the effect of androgens on lung diseases, such as asthma, chronic obstructive pulmonary disease and lung fibrosis. We also discuss the therapeutic use of androgens and how circulating androgens correlate with lung disease. In addition to human studies, we also discuss how mouse models have helped to uncover the effect of androgens on monocytes and macrophages in lung disease. Although the role of estrogen and other female hormones has been broadly analyzed in the literature, we focus on the new perspectives of androgens as modulators of the immune system that target myeloid cells during lung inflammation.
has issue date	2020-08-07(xsd:dateTime)
bibo:doi	10.3389/fimmu.2020.01698
bibo:pmid	32849595
has license	cc-by
sha1sum (hex)	892e045d12c03cc399f0de1e912909bfed65e776
schema:url	https://doi.org/10.3389/fimmu.2020.01698
resource representing a document's title	Androgen and Androgen Receptors as Regulators of Monocyte and Macrophage Biology in the Healthy and Diseased Lung
has PubMed Central identifier	PMC7426504
has PubMed identifier	32849595
schema:publication	Front Immunol
resource representing a document's body	covid:892e045d12c03cc399f0de1e912909bfed65e776#body_text
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