About: A flagellin-adjuvanted inactivated porcine epidemic diarrhea virus (PEDV) vaccine provides enhanced immune protection against PEDV challenge in piglets

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About: A flagellin-adjuvanted inactivated porcine epidemic diarrhea virus (PEDV) vaccine provides enhanced immune protection against PEDV challenge in piglets Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A flagellin-adjuvanted inactivated porcine epidemic diarrhea virus (PEDV) vaccine provides enhanced immune protection against PEDV challenge in piglets
Creator	Du, Luping Yu, Zhengyu Sun, Bing Xu, Xiangwei Li, · Guo, · Kongwang He, · Fan, · Shi, Danyi Zhou, Jinzhu
Source	Medline; PMC
abstract	Since late 2010, outbreaks of porcine epidemic diarrhea (PED) have been reported in the swine industry in China. A variant PEDV strain that differs from strain CV777 causes prevalent PEDV infections which commercial vaccines based on CV777 cannot provide complete protection. In this study, we designed a new vaccine based on the epidemic PEDV strain AH2012/12, adjuvanted with flagellin, a mucosal adjuvant that induces mucosal and systemic production of IgA. Three groups of pregnant sows were immunized twice, with a 14-day interval, with PEDV adjuvanted with flagellin, PEDV alone, or PBS before farrowing, and newborn piglets from each group were selected and challenged with PEDV. Immunization with this vaccine elicited high levels of IgG, IgA, and neutralizing antibodies in the serum and colostrum of sows, and newborn piglets were protected against PEDV while suckling. This study should guide the prevention and control strategies for PEDV infection, thereby reducing the losses associated with this virus.
has issue date	2020-04-06(xsd:dateTime)
bibo:doi	10.1007/s00705-020-04567-w
bibo:pmid	32253616
has license	no-cc
sha1sum (hex)	8935b100fd9ea43f7c187c935c86b2e3f2b3c239
schema:url	https://doi.org/10.1007/s00705-020-04567-w
resource representing a document's title	A flagellin-adjuvanted inactivated porcine epidemic diarrhea virus (PEDV) vaccine provides enhanced immune protection against PEDV challenge in piglets
has PubMed Central identifier	PMC7223252
has PubMed identifier	32253616
schema:publication	Arch Virol
resource representing a document's body	covid:8935b100fd9ea43f7c187c935c86b2e3f2b3c239#body_text
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