About: Cellular membrane cholesterol is required for porcine reproductive and respiratory syndrome virus entry and release in MARC-145 cells

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About: Cellular membrane cholesterol is required for porcine reproductive and respiratory syndrome virus entry and release in MARC-145 cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cellular membrane cholesterol is required for porcine reproductive and respiratory syndrome virus entry and release in MARC-145 cells
Creator	Sun, Ying Bin, L Dang, Wang Huanchun, Chen Liurong, Rui, Luo Shaobo, Xiao
Source	Medline; PMC
abstract	Cholesterol represents one of the key constituents of small, dynamic, sterol- and sphingolipid-enriched domains on the plasma membrane. It has been reported that many viruses depend on plasma membrane cholesterol for efficient infection. In this study, the role of the plasma membrane cholesterol in porcine reproductive and respiratory syndrome virus (PRRSV) infection of MARC-145 cells was investigated. Pretreatment of MARC-145 cells with methyl-β-cyclodextrin (MβCD), a drug used to deplete cholesterol from cellular membrane, significantly reduced PRRSV infection in a dose-dependent manner. This inhibition was partially reversed by supplementing exogenous cholesterol following MβCD treatment, suggesting that the inhibition of PRRSV infection was specifically mediated by removal of cellular cholesterol. Further detailed studies showed that depletion of cellular membrane cholesterol significantly inhibited virus entry, especially virus attachment and release. These results indicate that the presence of cholesterol in the cellular membrane is a key component of PRRSV infection.
has issue date	2011-12-16(xsd:dateTime)
bibo:doi	10.1007/s11427-011-4236-0
bibo:pmid	22173307
has license	cc-by-nc
sha1sum (hex)	893dca5fa5e77b64508bdb216d8e8538d60111e2
schema:url	https://doi.org/10.1007/s11427-011-4236-0
resource representing a document's title	Cellular membrane cholesterol is required for porcine reproductive and respiratory syndrome virus entry and release in MARC-145 cells
has PubMed Central identifier	PMC7088586
has PubMed identifier	22173307
schema:publication	Sci China Life Sci
resource representing a document's body	covid:893dca5fa5e77b64508bdb216d8e8538d60111e2#body_text
is schema:about of	named entity '145' named entity 'ENRICHED' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'DYNAMIC' named entity 'REQUIRED' named entity 'SMALL' named entity 'CITATION' named entity '145' named entity 'EXOGENOUS' named entity 'REVERSED' named entity 'STUDIES' named entity 'CELLULAR MEMBRANE' named entity 'RELEASE' named entity 'REDUCED' named entity 'STUDY' named entity 'FOLLOWING' named entity 'infection' named entity 'Further' named entity 'virus' named entity 'plasma membrane' named entity 'cellular membrane' named entity 'INVESTIGATED' named entity 'CELLS' named entity 'CELLULAR' named entity 'METHYL' named entity 'PARTIALLY' named entity 'RESULTS' named entity 'VIRUSES' named entity 'STEROL' named entity 'TREATMENT' named entity 'MEMBRANE FUSION' named entity 'SUPPLEMENTING' named entity 'DEPLETION' named entity 'REPORTED' named entity 'PRESENCE OF' named entity 'DEPEND' named entity 'REMOVAL' named entity 'SUN' named entity 'ONE OF' named entity 'THESE' named entity 'MARC' named entity 'INHIBITED' named entity 'PLASMA MEMBRANE' named entity 'INHIBITION' named entity 'EFFICIENT' named entity 'SPHINGOLIPID' named entity 'COMPONENT' named entity 'CONSTITUENTS' named entity 'WANG' named entity 'MARC' named entity 'CYCLODEXTRIN' named entity 'KEY' named entity 'IS A' named entity 'DRUG USED' named entity 'PRETREATMENT' named entity 'VIRUS ATTACHMENT' named entity 'MEDIATED' named entity 'DOSE-DEPENDENT' named entity 'DETAILED' named entity 'VIRUS ENTRY' named entity 'INFECTION' named entity 'ROLE' named entity 'CHOLESTEROL' named entity 'CELLS' covid:arg/893dca5fa5e77b64508bdb216d8e8538d60111e2 named entity 'respiratory' named entity 'Citation' named entity 'Xiao S' named entity 'inhibited' named entity 'partially' named entity 'virus' named entity 'constituents' named entity 'infection' named entity 'porcine' named entity 'cells'

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