About: Late‐onset noninfectious interstitial lung disease following autologous haematopoietic stem cell transplantation in paediatric patients

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About: Late‐onset noninfectious interstitial lung disease following autologous haematopoietic stem cell transplantation in paediatric patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Late‐onset noninfectious interstitial lung disease following autologous haematopoietic stem cell transplantation in paediatric patients
Creator	Ahn, Kangmo Kim, Jihyun Cho, Joongbum Sung, Ki Huh, Rimm Lee, Yoon-Kyoung
Source	Medline; PMC
abstract	BACKGROUND AND OBJECTIVE: High‐dose chemotherapy (HDCT) followed by autologous haematopoietic stem cell transplantation (HSCT) is widely used in paediatric cancer patients, but few data about noninfectious interstitial lung disease (ILD) following this treatment are available. Therefore, we aimed to evaluate the incidence, clinical features and risk factors of noninfectious ILD after HDCT in paediatric patients. METHODS: This was a retrospective cohort study of paediatric solid tumour patients who underwent HDCT and autologous HSCT between 1997 and 2012. ILD was diagnosed using clinical symptoms and radiography after excluding cardiac, renal and infectious causes. Risk factors were analysed using a Cox proportional hazard regression model. RESULTS: Three hundred and forty patients were enrolled, and the median age was 3 years (interquartile range 1–7). Eight patients (2.4%) were diagnosed with noninfectious ILD. The median duration of symptom onset was 30 months (range 7–74). Six (75%) of eight ILD patients died during the study period, even though steroids were administered for treatment. High‐dose cyclophosphamide use (hazard ratio = 11.37, 95% confidence interval = 1.38–93.32, P = 0.023) and sex (hazard ratio = 0.10, 95% confidence interval = 0.01–0.84, P = 0.034) were associated with late‐onset, noninfectious ILD upon multivariate analysis. CONCLUSION: The incidence of noninfectious ILD after HDCT and autologous HSCT was not negligible, and the clinical features of ILD showed late onset and a poor prognosis. Female gender and high‐dose cyclophosphamide treatment may be risk factors for noninfectious ILD, but further studies with a larger number of ILD patients are suggested.
has issue date	2016-04-12(xsd:dateTime)
bibo:doi	10.1111/resp.12787
bibo:pmid	27072744
has license	no-cc
sha1sum (hex)	8954dce787cdfd1452e571026426ea90a3c552af
schema:url	https://doi.org/10.1111/resp.12787
resource representing a document's title	Late‐onset noninfectious interstitial lung disease following autologous haematopoietic stem cell transplantation in paediatric patients
has PubMed Central identifier	PMC7169184
has PubMed identifier	27072744
schema:publication	Respirology
resource representing a document's body	covid:8954dce787cdfd1452e571026426ea90a3c552af#body_text
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