About: Dynamic Changes of Antibodies to SARS-CoV-2 in COVID-19 Patients at Early Stage of Outbreak

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About: Dynamic Changes of Antibodies to SARS-CoV-2 in COVID-19 Patients at Early Stage of Outbreak Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dynamic Changes of Antibodies to SARS-CoV-2 in COVID-19 Patients at Early Stage of Outbreak
Creator	Liu, Hong Zhou, Peng Wang, Yaxin Yuan, Shiying Pan, Shangwen Shu, Huaqing Wu, Yongran Li, Ruiting Ruan, Shunan Wang, Shuzhen Ouyang, Yaqi Zhang, Jiancheng Yuan, Yin Shang, •
Source	Medline; PMC
abstract	The coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has spread around the world with high mortality. To diagnose promptly and accurately is the vital step to effectively control its pandemic. Dynamic characteristics of SARS-CoV-2-specific antibodies which are important for diagnosis of infection have not been fully demonstrated. In this retrospective, single-center, observational study, we enrolled the initial 131 confirmed cases of COVID-19 at Jin-Yin-Tan Hospital who had at least one-time antibody tested during their hospitalization. The dynamic changes of IgM and IgG antibodies to SARS-CoV-2 nucleocapsid protein in 226 serum samples were detected by ELISA. The sensitivities of IgM and IgG ELISA detection were analyzed. Result showed that the sensitivity of the IgG ELISA detection (92.5%) was significantly higher than that of the IgM (70.8%) (P < 0.001). The meantimes of seroconversion for IgM and IgG were 6 days and 3 days, respectively. The IgM and IgG antibody levels peaked at around 18 days and 23 days, and then IgM fell to below the baseline level at about day 36, whereas IgG maintained at a relatively high level. In conclusion, antibodies should be detected to aid in diagnosis of COVID-19 infection. IgG could be a sensitive indicator for retrospective diagnosis and contact tracing, while IgM could be an indicator of early infection.
has issue date	2020-07-27(xsd:dateTime)
bibo:doi	10.1007/s12250-020-00268-5
bibo:pmid	32720214
has license	no-cc
sha1sum (hex)	89756378e6fdcc47cd0b5c4e9866ae69e82d6ce2
schema:url	https://doi.org/10.1007/s12250-020-00268-5
resource representing a document's title	Dynamic Changes of Antibodies to SARS-CoV-2 in COVID-19 Patients at Early Stage of Outbreak
has PubMed Central identifier	PMC7383121
has PubMed identifier	32720214
schema:publication	Virol Sin
resource representing a document's body	covid:89756378e6fdcc47cd0b5c4e9866ae69e82d6ce2#body_text
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