About: The Lord of the NanoRings: cyclodextrins and the battle against SARS-CoV-2

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About: The Lord of the NanoRings: cyclodextrins and the battle against SARS-CoV-2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Lord of the NanoRings: cyclodextrins and the battle against SARS-CoV-2
Creator	Garrido, P Blanco-González, Alexandre Cabezón, Alfonso Calvelo, Martín Conde, Daniel Garcia-Fandino, Rebeca Garrido, Pablo Piñeiro, Ángel Suárez, Fabián Veleiro, Uxía Blanco-González, A Cabezón, A Calvelo, M Conde, D Garcia-Fandino, R Piñeiro, A Suárez, F Veleiro, U
Source	Elsevier; Medline; PMC
abstract	A handful of singular structures and laws can be observed in nature. They are not always evident but, once discovered, it seems obvious how to take advantage of them. In chemistry, the discovery of reproducible patterns stimulates the imagination to develop new functional materials and technological or medical applications. Two clear examples are helical structures at different levels in biological polymers as well as ring and spherical structures of different size and composition. Rings are intuitively observed as holes able to thread elongated structures. A large number of real and fictional stories have rings as inanimate protagonists. The design, development or just discovering of a special ring has often been taken as a symbol of power or success. Several examples are the Piscatory Ring wore by the Pope of the Catholic Church, the NBA Championship ring and the One Ring created by the Dark Lord Sauron in the epic story The Lord of the Rings. In this work, we reveal the power of another extremely powerful kind of rings to fight against the pandemic which is currently affecting the whole world. These rings are as small as ∼1 nm of diameter and so versatile that they are able to participate in the attack of viruses, and specifically SARS-CoV-2, in a large range of different ways. This includes the encapsulation and transport of specific drugs, as adjuvants to stabilize proteins, vaccines or other molecules involved in the infection, as cholesterol trappers to destabilize the virus envelope, as carriers for RNA therapies, as direct antiviral drugs and even to rescue blood coagulation upon heparin treatment. “One ring to rule them all. One ring to find them. One ring to bring them all and in the darkness bind them.” J. R. R. Tolkien
has issue date	2020-07-25(xsd:dateTime)
bibo:doi	10.1016/j.ijpharm.2020.119689
bibo:pmid	32717282
has license	no-cc
sha1sum (hex)	897834c5a40114a52b48f0da5f7adb663f07fad8
schema:url	https://doi.org/10.1016/j.ijpharm.2020.119689
resource representing a document's title	The Lord of the NanoRings: cyclodextrins and the battle against SARS-CoV-2
has PubMed Central identifier	PMC7381410
has PubMed identifier	32717282
schema:publication	Int J Pharm
resource representing a document's body	covid:897834c5a40114a52b48f0da5f7adb663f07fad8#body_text
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