About: ECG changes after rabbit coronavirus infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	ECG changes after rabbit coronavirus infection
Creator	Baric, Ralph Yount, Boyd Alexander, Lorraine Baric, S David Small, J Geratz, Joachim Keene, Bruce
Source	Elsevier; Medline; PMC
abstract	Abstract This study examines the electrocardiographic (ECG) changes following rabbit coronavirus (RbCV) infection. We have shown that infection with RbCV results in the development of myocarditis and congestive heart failure and that some survivors of RbCV infection go on to develop dilated cardiomyopathy in the chronic phase. Serial ECGs were recorded on 31 RbCV-infected rabbits. Measurements of heart rate; P-R interval; QRS duration; QTc interval; and P-, QRS-, and T-wave voltages were taken. The recordings were also examined for disturbances of conduction, rhythm, and repolarization. The acute and subacute phases were characterized by sinus tachycardia with depressed R- and T-wave voltages as well as disturbances of conduction, rhythm, and repolarization. In most animals in the chronic phase, the sinus rate returned to near-baseline values with resolution of the QRS voltage changes. The ECG changes observed during RbCV infection are similar to the spectrum of interval/segment abnormalities, rhythm disturbances, conduction defects, and myocardial pathology seen in human myocarditis, heart failure, and dilated cardiomyopathy. Because animals often died suddenly in the absence of severe clinical signs of congestive heart failure during the acute phase, RbCV infection may increase ventricular vulnerability, resulting in sudden cardiac death. RbCV infection may provide a rare opportunity to study sudden cardiac death in an animal model in which the ventricle is capable of supporting ventricular fibrillation, and invasive techniques monitoring cardiac function can be performed.
has issue date	1999-01-31(xsd:dateTime)
bibo:doi	10.1016/s0022-0736(99)90018-3
bibo:pmid	10037086
has license	els-covid
sha1sum (hex)	89c1764db023518c70301bd34aa180d8c5d98e51
schema:url	https://doi.org/10.1016/s0022-0736%2899%2990018-3
resource representing a document's title	ECG changes after rabbit coronavirus infection
has PubMed Central identifier	PMC7131501
has PubMed identifier	10037086
schema:publication	Journal of Electrocardiology
resource representing a document's body	covid:89c1764db023518c70301bd34aa180d8c5d98e51#body_text
is schema:about of	named entity 'ECGs' named entity 'infection' named entity 'rabbits' named entity 'congestive heart failure' covid:arg/89c1764db023518c70301bd34aa180d8c5d98e51 named entity 'survivors' named entity 'congestive heart failure' named entity 'T-wave' named entity 'heart failure' named entity 'sinus tachycardia' named entity 'Measurements' named entity 'acute' named entity 'develop' named entity 'performed' named entity 'recordings' named entity 'dilated cardiomyopathy' named entity 'conduction' named entity 'ECGs' named entity 'myocarditis' named entity 'QRS' named entity 'heart failure' named entity 'clinical signs' named entity 'cardiac function' named entity 'QRS' named entity 'congestive heart failure' named entity 'Coronavirus Infection' named entity 'ECG' named entity 'sudden cardiac death' named entity 'QT interval' named entity 'sinus tachycardia' named entity 'viral myocarditis' named entity 'polygraph' named entity 'intramuscularly' named entity 'ECG' named entity 'ECGs' named entity 'ECG' named entity 'conduction defects' named entity 'heart rate' named entity 'QRS' named entity 'myocarditis' named entity 'ECG' named entity 'subacute' named entity 'QTc prolongation' named entity 'myocarditis' named entity 'Clinical signs' named entity 'subacute' named entity 'myocardium' named entity 'inflammatory' named entity 'edema' named entity 'vascular lesions' named entity 'heart rate' named entity 'prolongation of the QTc interval' named entity 'myocardium' named entity 'PR interval' named entity 'normal sinus rhythm' named entity 'euthanasia' named entity 'myocarditis' named entity 'ventricles' named entity 'subacute' named entity 'sinus tachycardia' named entity 'infectious dose' named entity 'sinus tachycardia' named entity 'dilated cardiomyopathy' named entity 'QRS' named entity 'infection' named entity 'sudden death' named entity 'infection' named entity 'pseudorabies virus' named entity 'QTc' named entity 'Quincy, Massachusetts' named entity 'viral infection' named entity 'acute phase' named entity 'infection' named entity 'direct current' named entity 'Fredericia'

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