About: Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection

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About: Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection
Creator	Zhang, Chao Zhao, Jincun Jia, Wenxu Shi, Xuanling Wang, Xinquan Zhang, Linqi Zhou, Panpan Perlman, Stanley Channappanavar, Rudragouda Zhou, Dongming Li, Mingxi Shan, Sisi Xu, Jiuyang Zhang, Shuyuan Zhou, Haixia
topic	covid:89c52fc69362dbc2c29ed79aa72928ad14dc4c80#this
source	Medline; PMC
abstract	The recently identified Middle East Respiratory Syndrome Coronavirus (MERS-CoV) causes severe and fatal acute respiratory illness in humans. However, no approved prophylactic and therapeutic interventions are currently available. The MERS-CoV envelope spike protein serves as a crucial target for neutralizing antibodies and vaccine development, as it plays a critical role in mediating viral entry through interactions with the cellular receptor, dipeptidyl peptidase 4 (DPP4). Here, we constructed a recombinant rare serotype of the chimpanzee adenovirus 68 (AdC68) that expresses full-length MERS-CoV S protein (AdC68-S). Single intranasal immunization with AdC68-S induced robust and sustained neutralizing antibody and T cell responses in BALB/c mice. In a human DPP4 knock-in (hDPP4-KI) mouse model, it completely protected against lethal challenge with a mouse-adapted MERS-CoV (MERS-CoV-MA). Passive transfer of immune sera to naïve hDPP4-KI mice also provided survival advantages from lethal MERS-CoV-MA challenge. Analysis of sera absorption and isolated monoclonal antibodies from immunized mice demonstrated that the potent and broad neutralizing activity was largely attributed to antibodies targeting the receptor binding domain (RBD) of the S protein. These results show that AdC68-S can induce protective immune responses in mice and represent a promising candidate for further development against MERS-CoV infection in both dromedaries and humans.
has issue date	2019-05-25(xsd:dateTime)
bibo:doi	10.1080/22221751.2019.1620083
bibo:pmid	31130102
has license	cc-by
sha1sum (hex)	89c52fc69362dbc2c29ed79aa72928ad14dc4c80
schema:url	https://doi.org/10.1080/22221751.2019.1620083
resource representing a document's title	Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection
has PubMed Central identifier	PMC6542157
has PubMed identifier	31130102
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:89c52fc69362dbc2c29ed79aa72928ad14dc4c80#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/89c52fc69362dbc2c29ed79aa72928ad14dc4c80
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