About: Toll/IL-1 domain-containing adaptor inducing IFN-β (TRIF) mediates innate immune responses in murine peritoneal mesothelial cells through TLR3 and TLR4 stimulation

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About: Toll/IL-1 domain-containing adaptor inducing IFN-β (TRIF) mediates innate immune responses in murine peritoneal mesothelial cells through TLR3 and TLR4 stimulation Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Toll/IL-1 domain-containing adaptor inducing IFN-β (TRIF) mediates innate immune responses in murine peritoneal mesothelial cells through TLR3 and TLR4 stimulation
Creator	Park, Jong-Hwan Hwang, Eun-Ha Kim, Tae-Hyoun Lee, Kyung-Bok Oh, Sang-Muk Yang, Soo-Jin
Source	Elsevier; Medline; PMC
abstract	Abstract Mesothelial cells are composed of monolayer of the entire surface of serosal cavities including pleural, pericardial, and peritoneal cavity. Although mesothelial cells are known to express multiple Toll-like receptors (TLRs) which contribute to trigger innate immune responses against infections, the precise molecular mechanism remains still unclear. In the present study, we investigated the role of Toll/IL-1 domain-containing adaptor inducing IFN-β (TRIF), one of the two major TLRs–adaptor molecules, on innate immune response induced by TLR3 and TLR4 stimulation in murine peritoneal mesothelial cells (PMCs). TRIF was strongly expressed in PMCs and its deficiency led to impaired production of cytokines and chemokines by poly I:C and LPS in the cells. Activation of NF-κB or MAPKs through poly I:C and LPS stimulation was reduced in TRIF-deficient PMCs as compared to the WT cells. TRIF was also necessary for optimal nitric oxide synthesis and gene expression of inducible nitric oxide synthase (iNOS) and IFN-β in PMCs in response to poly I:C and LPS. Furthermore, both Escherichia coli and Pseudomonas aeruginosa induced high level of IL-6, CXCL1, and CCL2 production in PMCs, which was significantly impaired by TRIF deficiency. These results demonstrated that TRIF is required for optimal activation of innate immune responses in mesothelial cells against microbial infections.
has issue date	2016-01-31(xsd:dateTime)
bibo:doi	10.1016/j.cyto.2015.11.010
bibo:pmid	26579632
has license	els-covid
sha1sum (hex)	89e496268c8ce4f434bfc622cd9ec4339577c885
schema:url	https://doi.org/10.1016/j.cyto.2015.11.010
resource representing a document's title	Toll/IL-1 domain-containing adaptor inducing IFN-β (TRIF) mediates innate immune responses in murine peritoneal mesothelial cells through TLR3 and TLR4 stimulation
has PubMed Central identifier	PMC7128242
has PubMed identifier	26579632
schema:publication	Cytokine
resource representing a document's body	covid:89e496268c8ce4f434bfc622cd9ec4339577c885#body_text
is schema:about of	named entity 'study' named entity 'Although' named entity 'expression' named entity 'chemokines' named entity 'cells' named entity 'adaptor' named entity 'cells' named entity 'murine' named entity 'MEDIATES' named entity 'STIMULATION' named entity 'IMMUNE RESPONSES' named entity 'PERITONEAL' named entity 'INFECTIONS' named entity 'RESPONSE TO' named entity 'CCL2 PRODUCTION' named entity 'REQUIRED' named entity 'KNOWN' named entity 'PERICARDIAL' named entity 'ACTIVATION' named entity 'DOMAIN' named entity 'CELLS' named entity 'IMPAIRED' named entity 'STIMULATION' named entity 'IMMUNE RESPONSES' named entity 'TOLL' named entity 'UNCLEAR' named entity 'MOLECULAR MECHANISM' named entity 'TLR4' named entity 'IFN' named entity 'RESULTS' named entity 'ADAPTOR' named entity 'CONTAINING' named entity 'MURINE' named entity 'TLR4' named entity 'PERITONEAL' named entity 'MESOTHELIAL CELLS' named entity 'TLR3' named entity 'IFN' named entity 'ADAPTOR' named entity 'COMPARED' named entity 'DOMAIN' named entity 'EXPRESSED' named entity 'DEFICIENT' named entity 'PRODUCTION' named entity 'HIGH LEVEL' named entity 'ROLE' named entity 'PERITONEAL CAVITY' named entity 'INDUCING' named entity 'CXCL1' named entity 'LPS' named entity 'MAPKS' named entity 'NITRIC OXIDE SYNTHESIS' named entity 'TOLL-LIKE RECEPTORS' named entity 'INNATE IMMUNE RESPONSE' named entity 'TLRS' named entity 'MICROBIAL' named entity 'PRESENT' named entity 'POLY I' named entity 'TOLL' named entity 'PLEURAL' named entity 'REDUCED' named entity 'THESE' named entity 'MULTIPLE' named entity 'ITS' named entity 'INDUCED' named entity 'MESOTHELIAL CELLS' named entity 'IL-6' named entity 'PRECISE' named entity 'DEMONSTRATED' named entity 'INCLUDING' named entity 'MONOLAYER' named entity 'ONE OF' named entity 'CONTAINING' named entity 'SEROSAL' named entity 'MOLECULES' named entity 'ESCHERICHIA COLI'

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