About: Chest CT accuracy in diagnosing COVID-19 during the peak of the Italian epidemic: A retrospective correlation with RT-PCR testing and analysis of discordant cases

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About: Chest CT accuracy in diagnosing COVID-19 during the peak of the Italian epidemic: A retrospective correlation with RT-PCR testing and analysis of discordant cases Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chest CT accuracy in diagnosing COVID-19 during the peak of the Italian epidemic: A retrospective correlation with RT-PCR testing and analysis of discordant cases
Creator	Andreoni, Stefano Barini, Michela Carriero, Alessandro Falaschi, Zeno Aquilini, Ferruccio Arioli, Roberto Danna, Pietro Pasché, Alessio Percivale, Ilaria Tricca, Stefano Zagaria, Domenico
Source	Elsevier; Medline; PMC
abstract	OBJECTIVES: The goal of this study was to assess chest computed tomography (CT) diagnostic accuracy in clinical practice using RT-PCR as standard of reference. METHODS: From March 4th to April 9th 2020, during the peak of the Italian COVID-19 epidemic, we enrolled a series of 773 patients that performed both non-contrast chest CT and RT-PCR with a time interval no longer than a week due to suspected SARS-CoV-2 infection. The diagnostic performance of CT was evaluated according to sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy, considering RT-PCR as the reference standard. An analysis on the patients with discrepant CT scan and RT-PCR result and on the patient with both negative tests was performed. RESULTS: RT-PCR testing showed an overall positive rate of 59.8 %. CT sensitivity, specificity, PPV, NPV, and accuracy for SARS-CoV-2 infection were 90.7 % [95 % IC, 87.7%–93.2%], 78.8 % [95 % IC, 73.8−83.2%], 86.4 % [95 % IC, 76.1 %–88.9 %], 85.1 % [95 % IC, 81.0 %–88.4] and 85.9 % [95 % IC 83.2−88.3%], respectively. Twenty-five/66 (37.6 %) patients with positive CT and negative RT-PCR results and 12/245 (4.9 %) patients with both negative tests were nevertheless judged as positive cases by the clinicians based on clinical and epidemiological criteria and consequently treated. CONCLUSIONS: In our experience, in a context of high pre-test probability, CT scan shows good sensitivity and a consistently higher specificity for the diagnosis of COVID-19 pneumonia than what reported by previous studies, especially when clinical and epidemiological features are taken into account.
has issue date	2020-07-25(xsd:dateTime)
bibo:doi	10.1016/j.ejrad.2020.109192
bibo:pmid	32738464
has license	no-cc
sha1sum (hex)	89f00a491a72dfb716f01487c38ae042bfa5c446
schema:url	https://doi.org/10.1016/j.ejrad.2020.109192
resource representing a document's title	Chest CT accuracy in diagnosing COVID-19 during the peak of the Italian epidemic: A retrospective correlation with RT-PCR testing and analysis of discordant cases
has PubMed Central identifier	PMC7382359
has PubMed identifier	32738464
schema:publication	Eur J Radiol
resource representing a document's body	covid:89f00a491a72dfb716f01487c38ae042bfa5c446#body_text
is schema:about of	named entity 'April 9th' named entity 'March' named entity 'suspected' named entity 'predictive' named entity 'specificity' named entity 'Chest' named entity 'SPECIFICITY' named entity '9TH' named entity 'CASES' named entity 'DUE TO' named entity 'positive' named entity 'chest' named entity 'NPV' named entity 'performed' named entity 'performance' named entity 'Methods' named entity 'NPV' named entity 'clinical practice' named entity 'NPV' named entity 'PPV' named entity 'RT-PCR' named entity 'diagnostic accuracy' named entity 'RT-PCR' named entity 'RT-PCR' named entity 'diagnostic accuracy' named entity 'COVID-19' named entity 'sensitivity, specificity' named entity 'COVID-19' named entity 'RT-PCR' named entity 'PPV' named entity 'RT-PCR test' named entity 'Radiology department' named entity 'RT-PCR' named entity 'chest CT' named entity 'ground glass opacity' named entity 'meta-analysis' named entity 'CHF' named entity 'PPV' named entity 'tube voltage' named entity 'critically ill patients' named entity 'CHF' named entity 'epidemic' named entity 'pneumonia' named entity 'CT scans' named entity 'COVID' named entity 'functional impairment' named entity 'Diagnostic accuracy' named entity 'pericardial effusion' named entity 'CT scans' named entity 'NPV' named entity 'radiographic' named entity 'pre-test probability' named entity 'chest CT' named entity 'Chest CT' named entity 'COVID-19' named entity 'CT scans' named entity 'RT-PCR' named entity 'COVID-19' named entity 'Novara' named entity 'chest CT' named entity 'RT-PCR' named entity 'CT scan' named entity 'chronic heart failure' named entity 'coronal view' named entity 'RT-PCR' named entity 'Chest CT' named entity 'lung' named entity 'Italy' named entity 'Nasopharyngeal' named entity 'Italy' named entity 'GGO'

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