About: Animal Models for Target Diseases in Gene Therapy — using DNA and siRNA Delivery Strategies

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About: Animal Models for Target Diseases in Gene Therapy — using DNA and siRNA Delivery Strategies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Animal Models for Target Diseases in Gene Therapy — using DNA and siRNA Delivery Strategies
Creator	Blagbrough, Ian Zara, Chiara
source	Medline; PMC
abstract	Nanoparticles, including lipopolyamines leading to lipoplexes, liposomes, and polyplexes are targeted drug carrier systems in the current search for a successful delivery system for polynucleic acids. This review is focused on the impact of gene and siRNA delivery for studies of efficacy, pharmacodynamics, and pharmacokinetics within the setting of the wide variety of in vivo animal models now used. This critical appraisal of the recent literature sets out the different models that are currently being investigated to bridge from studies in cell lines through towards clinical reality. Whilst many scientists will be familiar with rodent (murine, fecine, cricetine, and musteline) models, few probably think of fish as a clinically relevant animal model, but zebrafish, madake, and rainbow trout are all being used. Larger animal models include rabbit, cat, dog, and cow. Pig is used both for the prevention of foot-and-mouth disease and human diseases, sheep is a model for corneal transplantation, and the horse naturally develops arthritis. Non-human primate models (macaque, common marmoset, owl monkey) are used for preclinical gene vector safety and efficacy trials to bridge the gap prior to clinical studies. We aim for the safe development of clinically effective delivery systems for DNA and RNAi technologies.
has issue date	2008-10-08(xsd:dateTime)
bibo:doi	10.1007/s11095-008-9646-8
bibo:pmid	18841450
has license	no-cc
sha1sum (hex)	8a269fa8dda9cf98a04b57d5762195e83e618a8d
schema:url	https://doi.org/10.1007/s11095-008-9646-8
resource representing a document's title	Animal Models for Target Diseases in Gene Therapy — using DNA and siRNA Delivery Strategies
has PubMed Central identifier	PMC7088656
has PubMed identifier	18841450
schema:publication	Pharm Res
resource representing a document's body	covid:8a269fa8dda9cf98a04b57d5762195e83e618a8d#body_text
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