About: First case of COVID-19 complicated with fulminant myocarditis: a case report and insights

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	First case of COVID-19 complicated with fulminant myocarditis: a case report and insights
Creator	Feng, Cheng Liu, Lei Yuan, Jing Gao, Hong Li, Jin-Xiu Liu, Ying-Xia Li, · Liu, · Feng, · Dong, Chang-Feng Fu, · Wu, Wei-Bo Yao, · Zeng, Jia-Hui Zeng, J.-H Li, Yi-Jun Xie, Xiao-Juan Wang, -Fei Wang, -Xiang
source	Medline; PMC
abstract	BACKGROUND: Coronavirus disease 2019 (COVID-19) has been demonstrated to be the cause of pneumonia. Nevertheless, it has not been reported as the cause of acute myocarditis or fulminant myocarditis. CASE PRESENTATION: A 63-year-old male was admitted with pneumonia and cardiac symptoms. He was genetically confirmed as having COVID-19 according to sputum testing on the day of admission. He also had elevated troponin I (Trop I) level (up to 11.37 g/L) and diffuse myocardial dyskinesia along with a decreased left ventricular ejection fraction (LVEF) on echocardiography. The highest level of interleukin-6 was 272.40 pg/ml. Bedside chest radiographs showed typical ground-glass changes indicative of viral pneumonia. Laboratory test results for viruses that cause myocarditis were all negative. The patient conformed to the diagnostic criteria of the Chinese expert consensus statement for fulminant myocarditis. After receiving antiviral therapy and mechanical life support, Trop I was reduced to 0.10 g/L, and interleukin-6 was reduced to 7.63 pg/mL. Moreover, the LVEF of the patient gradually recovered to 68%. The patient died of aggravation of secondary infection on the 33rd day of hospitalization. CONCLUSION: COVID-19 patients may develop severe cardiac complications such as myocarditis and heart failure. This is the first report of COVID-19 complicated with fulminant myocarditis. The mechanism of cardiac pathology caused by COVID-19 needs further study.
has issue date	2020-04-10(xsd:dateTime)
bibo:doi	10.1007/s15010-020-01424-5
bibo:pmid	32277408
has license	no-cc
sha1sum (hex)	8a33ea505c5bd08d6923f01a7839b19404584400
schema:url	https://doi.org/10.1007/s15010-020-01424-5
resource representing a document's title	First case of COVID-19 complicated with fulminant myocarditis: a case report and insights
has PubMed Central identifier	PMC7146072
has PubMed identifier	32277408
schema:publication	Infection
resource representing a document's body	covid:8a33ea505c5bd08d6923f01a7839b19404584400#body_text
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