About: Immunisation of pigs with a major envelope protein sub-unit vaccine against porcine reproductive and respiratory syndrome virus (PRRSV) results in enhanced clinical disease following experimental challenge

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About: Immunisation of pigs with a major envelope protein sub-unit vaccine against porcine reproductive and respiratory syndrome virus (PRRSV) results in enhanced clinical disease following experimental challenge Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunisation of pigs with a major envelope protein sub-unit vaccine against porcine reproductive and respiratory syndrome virus (PRRSV) results in enhanced clinical disease following experimental challenge
Creator	Simarro, Isabel Aguilar-Calvo, Patricia Castro, José Díez-Fuertes, Francisco Prieto, Cinta Javier Martínez-Lobo, Francisco
Source	Elsevier; Medline; PMC
abstract	Abstract Disease exacerbation was observed in pigs challenged with virulent porcine reproductive and respiratory syndrome virus (PRRSV) following immunisation with a recombinant GP5 sub-unit PRRSV vaccine (rGP5) produced in E. coli. Eighteen animals were divided into three experimental groups: group A were immunised twice IM with rGP5, 21days apart; group B acted as positive controls (challenged but not immunised); and group C were negative controls. Pigs in groups A and B were challenged 21days after the second immunisation of the group A animals. Following challenge, three pigs given rGP5 exhibited more severe clinical signs than the positive controls, including respiratory distress and progressive weight-loss. Although not statistically significant, the more severe disease exhibited by group A animals may suggest previous immunisation as a contributory factor. The mechanisms of these findings remain unclear and no association could be established between the severity of disease, non-neutralising antibody concentrations and tissue viral loads.
has issue date	2011-09-30(xsd:dateTime)
bibo:doi	10.1016/j.tvjl.2010.07.010
bibo:pmid	20713312
has license	els-covid
sha1sum (hex)	8a39f14301511311ce0f762caf653fca753c8f04
schema:url	https://doi.org/10.1016/j.tvjl.2010.07.010
resource representing a document's title	Immunisation of pigs with a major envelope protein sub-unit vaccine against porcine reproductive and respiratory syndrome virus (PRRSV) results in enhanced clinical disease following experimental challenge
has PubMed Central identifier	PMC7172774
has PubMed identifier	20713312
schema:publication	The Veterinary Journal
resource representing a document's body	covid:8a39f14301511311ce0f762caf653fca753c8f04#body_text
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