About: Interplay of foot-and-mouth disease virus, antibodies and plasmacytoid dendritic cells: virus opsonization under non-neutralizing conditions results in enhanced interferon-alpha responses

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About: Interplay of foot-and-mouth disease virus, antibodies and plasmacytoid dendritic cells: virus opsonization under non-neutralizing conditions results in enhanced interferon-alpha responses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interplay of foot-and-mouth disease virus, antibodies and plasmacytoid dendritic cells: virus opsonization under non-neutralizing conditions results in enhanced interferon-alpha responses
Creator	Lannes, Nils Python, Sylvie Summerfield, Artur
Source	Medline; PMC
abstract	Foot-and-mouth disease virus (FMDV) is a highly infectious member of the Picornaviridae inducing an acute disease of cloven-hoofed species. Vaccine-induced immune protection correlates with the presence of high levels of neutralizing antibodies but also opsonising antibodies have been proposed as an important mechanism of the immune response contributing to virus clearance by macrophages and leading to the production of type-I interferon (IFN) by plasmacytoid dendritic cells (pDC). The present study demonstrates that the opsonising antibody titres mediating enhanced IFN-α responses in pDC were similar to neutralizing titres, when antigenically related viruses from the same serotype were employed. However, sera cross-reacted also with non-neutralized isolates of multiple serotypes, when tested in this assay. Both uncomplexed virus and immune complexed virus stimulated pDC via Toll-like receptor 7. An additional finding of potential importance for strain-specific differences in virulence and/or immunogenicity was that pDC activation by FMDV strongly differed between viral isolates. Altogether, our results indicate that opsonising antibodies can have a broader reactivity than neutralizing antibodies and may contribute to antiviral responses induced against antigenically distant viruses.
has issue date	2012-08-30(xsd:dateTime)
bibo:doi	10.1186/1297-9716-43-64
bibo:pmid	22934974
has license	cc-by
sha1sum (hex)	8a6f367d81903273daadb6e142149f2feff80d6e
schema:url	https://doi.org/10.1186/1297-9716-43-64
resource representing a document's title	Interplay of foot-and-mouth disease virus, antibodies and plasmacytoid dendritic cells: virus opsonization under non-neutralizing conditions results in enhanced interferon-alpha responses
has PubMed Central identifier	PMC3479418
has PubMed identifier	22934974
schema:publication	Vet Res
resource representing a document's body	covid:8a6f367d81903273daadb6e142149f2feff80d6e#body_text
is schema:about of	named entity 'antiviral' named entity 'immune' named entity 'Both' named entity 'high' named entity 'levels' named entity 'antibodies' named entity 'conditions' named entity 'ENHANCED' named entity 'TESTED' named entity 'HOOFED' named entity 'DISTANT' named entity 'PLASMACYTOID' named entity 'RESPONSES' named entity 'PLASMACYTOID' named entity 'CONTRIBUTE ' named entity 'SPECIFIC' named entity 'INTERFERON ' named entity 'NEUTRALIZING ANTIBODIES' named entity 'MEDIATING' named entity 'IMMUNE RESPONSE' covid:arg/8a6f367d81903273daadb6e142149f2feff80d6e named entity 'RESPONSES' named entity 'TOLL-LIKE RECEPTOR 7' named entity 'STIMULATED' named entity 'LEADING' named entity 'EMPLOYED' named entity 'OPSONIZATION' named entity 'FOOT-AND-MOUTH DISEASE VIRUS' named entity 'INDUCED' named entity 'ASSAY' named entity 'HAVE' named entity 'ISOLATES' named entity 'INTERFERON-ALPHA' named entity 'NON-' named entity 'VIRUS' named entity 'ANTIVIRAL' named entity 'CROSS' named entity 'BUT' named entity 'TYPE' named entity 'RESULTS' named entity 'IMPORTANT' named entity 'HIGHLY' named entity 'VIRUS CLEARANCE' named entity 'ANTIBODIES' named entity 'INDUCING' named entity 'STRAIN' named entity 'ENHANCED' named entity 'IS A' named entity 'VIRAL' named entity 'PROPOSED' named entity 'VIRUS' named entity 'MACROPHAGES' named entity 'FOOT-AND-MOUTH DISEASE VIRUS' named entity 'HIGH' named entity 'CONTRIBUTING' named entity 'NON-' named entity 'PRESENCE OF' named entity 'VIRUSES' named entity 'FMDV' named entity 'MULTIPLE' named entity 'DENDRITIC CELLS' named entity 'VIRULENCE' named entity 'ACTIVATION' named entity 'MEMBER OF' named entity 'FINDING' named entity 'PDC' named entity 'IMMUNE' named entity 'PRODUCTION' named entity 'POTENTIAL' named entity 'SPECIES' named entity 'STUDY' named entity 'ADDITIONAL' named entity 'ACUTE DISEASE' named entity 'RELATED' named entity 'IMMUNE PROTECTION' named entity 'MECHANISM' named entity 'ANTIBODY TITRES' named entity 'LEVELS' named entity 'IMMUNOGENICITY'

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