About: Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2

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About: Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2
Creator	Case, James Whelan, Sean Liu, Zhuoming Chen, Rita Rothlauf, Paul Chou, Yi-Ying Cureton, David Diamond, Kang, Yuan-Lin Kirchhausen, Tom Soh, K
Source	BioRxiv; Medline
abstract	Virus entry is a multistep process. It initiates when the virus attaches to the host cell and ends when the viral contents reach the cytosol. Genetically unrelated viruses can subvert analogous subcellular mechanisms and use similar trafficking pathways for successful entry. Antiviral strategies targeting early steps of infection are therefore appealing, particularly when the probability for successful interference through a common step is highest. We describe here potent inhibitory effects on content release and infection by chimeric VSV containing the envelope proteins of Zaire ebolavirus (VSV-ZEBOV) or SARS-CoV-2 (VSV-SARS-CoV-2) elicited by Apilimod and Vacuolin-1, small molecule inhibitors of the main endosomal Phosphatidylinositol-3-Phosphate/Phosphatidylinositol 5-Kinase, PIKfyve. We also describe potent inhibition of SARS-CoV-2 strain 2019-nCoV/USA-WA1/2020 by Apilimod. These results define new tools for studying the intracellular trafficking of pathogens elicited by inhibition of PIKfyve kinase and suggest the potential for targeting this kinase in developing small-molecule antivirals against SARS-CoV-2.
has issue date	2020-06-15(xsd:dateTime)
bibo:doi	10.1101/2020.04.21.053058
bibo:pmid	32511398
has license	biorxiv
sha1sum (hex)	8a8188c6578944389667d06617980d37c68f9921
schema:url	https://doi.org/10.1101/2020.04.21.053058
resource representing a document's title	Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2
has PubMed identifier	32511398
schema:publication	bioRxiv
resource representing a document's body	covid:8a8188c6578944389667d06617980d37c68f9921#body_text
is schema:about of	named entity 'trafficking' named entity 'SARS-CoV' named entity 'tools' named entity 'antivirals' named entity 'successful' named entity 'chimeric' named entity 'kinase' named entity 'Running' named entity 'MOLECULE' named entity 'A COMMON' named entity 'VIRAL' named entity 'VIRUS ENTRY' named entity 'STRATEGIES' named entity 'PHOSPHATIDYLINOSITOL' named entity 'MAIN' named entity 'UNRELATED' named entity 'IS A' named entity 'DESCRIBE' named entity 'ZAIRE EBOLAVIRUS' named entity 'ENVELOPE' named entity 'APILIMOD' named entity 'SARS-COV' named entity 'WA1' covid:arg/8a8188c6578944389667d06617980d37c68f9921 named entity 'developing' named entity 'Phosphatidylinositol' named entity 'cytosol' named entity 'subvert' named entity 'SARS-CoV-2' named entity 'subcellular' named entity 'cell' named entity 'describe' named entity 'SARS-CoV-2' named entity 'strain' named entity 'analogous' named entity '2019-nCoV' named entity 'pathogens' named entity 'envelope proteins' named entity 'kinase' named entity 'SARS-CoV-2' named entity 'Kinase' named entity 'Apilimod' named entity 'Zaire ebolavirus' named entity 'kinase' named entity 'infection' named entity 'viruses' named entity 'endosomal' named entity 'LASV' named entity 'alpha-dystroglycan' named entity 'endosomal' named entity 'primers' named entity 'lysosomal' named entity 'LCMV' named entity 'severe acute respiratory syndrome coronavirus' named entity 'SARS-CoV-2' named entity 'Bafilomycin A1' named entity 'membrane protein' named entity 'alpha-dystroglycan' named entity 'infection' named entity 'LAMP1' named entity 'Lassa fever virus' named entity 'SARS' named entity 'low pH' named entity 'plasma membrane' named entity 'membrane fusion' named entity 'Lymphocytic choriomeningitis virus' named entity 'infection' named entity 'receptor protein' named entity 'lysosomal' named entity 'late endosomal' named entity 'vacuolar' named entity 'ATPase'

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