About: The Ebola clinical trials: a precedent for research ethics in disasters

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Ebola clinical trials: a precedent for research ethics in disasters
Creator	Calain, Philippe
topic	covid:8ac886d6b20755b99f0d627f55536e4cc0d6107c#this
Source	Medline; PMC
abstract	The West African Ebola epidemic has set in motion a collective endeavour to conduct accelerated clinical trials, testing unproven but potentially lifesaving interventions in the course of a major public health crisis. This unprecedented effort was supported by the recommendations of an ad hoc ethics panel convened in August 2014 by the WHO. By considering why and on what conditions the exceptional circumstances of the Ebola epidemic justified the use of unproven interventions, the panel's recommendations have challenged conventional thinking about therapeutic development and clinical research ethics. At the same time, unanswered ethical questions have emerged, in particular: (i) the specification of exceptional circumstances, (ii) the specification of unproven interventions, (iii) the goals of interventional research in terms of individual versus collective interests, (iv) the place of adaptive trial designs and (v) the exact meaning of compassionate use with unapproved interventions. Examination of these questions, in parallel with empirical data from research sites, will help build pragmatic foundations for disaster research ethics. Furthermore, the Ebola clinical trials signal an evolution in the current paradigms of therapeutic research, beyond the case of epidemic emergencies.
has issue date	2016-08-29(xsd:dateTime)
bibo:doi	10.1136/medethics-2016-103474
bibo:pmid	27573153
has license	cc-by-nc
sha1sum (hex)	8ac886d6b20755b99f0d627f55536e4cc0d6107c
schema:url	https://doi.org/10.1136/medethics-2016-103474
resource representing a document's title	The Ebola clinical trials: a precedent for research ethics in disasters
has PubMed Central identifier	PMC5749307
has PubMed identifier	27573153
schema:publication	J Med Ethics
resource representing a document's body	covid:8ac886d6b20755b99f0d627f55536e4cc0d6107c#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/8ac886d6b20755b99f0d627f55536e4cc0d6107c
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