About: Host gene expression profiles in ferrets infected with genetically distinct henipavirus strains

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Host gene expression profiles in ferrets infected with genetically distinct henipavirus strains
Creator	Borisevich, Viktoriya Xu, Luoling Rockx, Barry Kelvin, David Escaffre, Olivier Seymour, Robert Boroumand, Nahal Nusbaum, Rebecca
Source	Medline; PMC
abstract	Henipavirus infection causes severe respiratory and neurological disease in humans that can be fatal. To characterize the pathogenic mechanisms of henipavirus infection in vivo, we performed experimental infections in ferrets followed by genome-wide gene expression analysis of lung and brain tissues. The Hendra, Nipah-Bangladesh, and Nipah-Malaysia strains caused severe respiratory and neurological disease with animals succumbing around 7 days post infection. Despite the presence of abundant viral shedding, animal-to-animal transmission did not occur. The host gene expression profiles of the lung tissue showed early activation of interferon responses and subsequent expression of inflammation-related genes that coincided with the clinical deterioration. Additionally, the lung tissue showed unchanged levels of lymphocyte markers and progressive downregulation of cell cycle genes and extracellular matrix components. Infection in the brain resulted in a limited breadth of the host responses, which is in accordance with the immunoprivileged status of this organ. Finally, we propose a model of the pathogenic mechanisms of henipavirus infection that integrates multiple components of the host responses.
has issue date	2018-03-14(xsd:dateTime)
bibo:doi	10.1371/journal.pntd.0006343
bibo:pmid	29538374
has license	cc-by
sha1sum (hex)	8ace20b674c2bc5f71e195f68c703f66efd97b8b
schema:url	https://doi.org/10.1371/journal.pntd.0006343
resource representing a document's title	Host gene expression profiles in ferrets infected with genetically distinct henipavirus strains
has PubMed Central identifier	PMC5868854
has PubMed identifier	29538374
schema:publication	PLoS Negl Trop Dis
resource representing a document's body	covid:8ace20b674c2bc5f71e195f68c703f66efd97b8b#body_text
is schema:about of	named entity '283' named entity 'HOST' named entity 'LEON' named entity 'HENIPAVIRUS' named entity 'DIS' named entity 'HOST' named entity 'GENE EXPRESSION PROFILES' named entity 'CITATION' named entity 'SEYMOUR' named entity 'OPEN' named entity 'ORG' named entity 'INFECTED' named entity 'FERRETS' named entity 'HENIPAVIRUS' named entity 'STRAINS' named entity 'DISTINCT' named entity 'INFECTED' named entity 'STRAINS' named entity 'DISTINCT' named entity 'HTTPS' named entity 'ACCESS' named entity 'FERRETS' named entity 'GENE EXPRESSION PROFILES' covid:arg/8ace20b674c2bc5f71e195f68c703f66efd97b8b named entity 'henipavirus' named entity 'OPEN ACCESS' named entity 'gene expression profiles' named entity 'expression profiles' named entity 'CXCL10' named entity 'Reed-Muench method' named entity 'upregulation' named entity 'infection' named entity 'spleen' named entity 'lymphocytes' named entity 'lower respiratory tract' named entity 'necropsy' named entity 'virus' named entity 'lungs' named entity 'infection' named entity 'infection' named entity 'Qiagen' named entity 'NiV' named entity 'cellular immune responses' named entity 'gene repression' named entity 'digestion' named entity 'brain tissue' named entity 'Applied Biosystems' named entity 'infection' named entity 'BMDS' named entity 'CX3CL1' named entity 'vomiting' named entity 'Chemotaxis' named entity 'gene' named entity 'virus' named entity 'lymphocyte' named entity 'wild-type' named entity 'expression levels' named entity 'extracellular matrix' named entity 'antiviral' named entity 'cDNA sequencing' named entity 'Singapore' named entity 'lung tissue' named entity 'assay' named entity 'infection' named entity 'quantitative RT-PCR' named entity 'infection' named entity 'CD8A' named entity 'signaling pathways' named entity 'gene expression' named entity 'Bangladesh' named entity 'pathogenesis' named entity 'viruses' named entity 'ferret' named entity 'humoral'

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