About: Inflammatory Cytokine Modulation of Cancer Cell Proliferation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inflammatory Cytokine Modulation of Cancer Cell Proliferation
Creator	Thiel, Steffen Astrinidou-Vakaloudi, A Diamanti, I Georgakopoulou, E Hans, Reinholdt Hoffmann, Jürgen Jesper, Ralf Xatzidimitriou, D Xytsas, S
Source	PMC
abstract	Inflammatory cytokines have a critical role in modulation of both innate and adaptive immunity in response to foreign antigen. They also play an important role in anticancer immunity. For example, they can promote cell‐mediated immunity against cancer cells. With their immunostimulatory effects, these cytokines are being tested for cancer treatment in the form of DNA vaccine or adjuvant or therapeutic cytokines. Direct effect of these cytokines on cancer cell, however, is still unclear. In this project, we investigated whether IL‐1( and IL‐18 can modulate cancer cell proliferation. We employed a simple nonradioactive proliferation (MTT) assay and detection of lactate dehydrogenase (LDH) to test the effect of these recombinant human cytokines on various cancer cell lines, including breast cancer cell line (MCF‐7), oral carcinoma cell line (KB), colon cancer cell line (Caco‐2) and choriocarcinoma cell line (Jar). Cytokines used in this study had both inhibitory and stimulatory effect on cell proliferation. Findings in this project could provide an insight of cancer cell response to these cytokines and this could lead to a consideration on using cytokine as immunotherapy for cancer treatment.
has issue date	2008-06-28(xsd:dateTime)
bibo:doi	10.1111/j.0300-9475.2004.01423bi.x
has license	no-cc
sha1sum (hex)	8ae51d0ed7f867f203f87d38be24cb92b8587c6f
schema:url	https://doi.org/10.1111/j.0300-9475.2004.01423bi.x
resource representing a document's title	Inflammatory Cytokine Modulation of Cancer Cell Proliferation
has PubMed Central identifier	PMC7169513
schema:publication	Scand J Immunol
resource representing a document's body	covid:8ae51d0ed7f867f203f87d38be24cb92b8587c6f#body_text
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