About: Interferon-Induced Transmembrane Protein 1 (IFITM1) Promotes Distant Metastasis of Small Cell Lung Cancer

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About: Interferon-Induced Transmembrane Protein 1 (IFITM1) Promotes Distant Metastasis of Small Cell Lung Cancer Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon-Induced Transmembrane Protein 1 (IFITM1) Promotes Distant Metastasis of Small Cell Lung Cancer
Creator	Inoue, Hiroyuki Kawada, Manabu Kohda, Yasuko Mizutani, Taketoshi Ohba, Shun-Ichi Sakamoto, Shuichi
Source	Medline; PMC
abstract	Small cell lung cancer (SCLC) is a severe malignancy associated with early and widespread metastasis. To study SCLC metastasis, we previously developed an orthotopic transplantation model using the human SCLC cell line DMS273. In the model, metastatic foci were found in distant tissues such as bone and the adrenal gland, similarly as observed in patients with SCLC. In this study, we evaluated the differentially expressed genes between orthotopic and metastatic tumors in the model. We isolated tumor cells from orthotopic and metastatic sites, and the tumor cell RNA was analyzed using DNA microarray analysis. We found that 19 genes in metastatic tumors were upregulated by more than 4-fold compared with their expression in orthotopic tumors. One of these genes encodes a transmembrane protein, interferon (IFN)-induced transmembrane protein 1 (IFITM1), and immunohistochemical analysis confirmed the higher expression of the protein in metastatic sites than in orthotopic sites. IFITM1 was also detected in some SCLC cell lines and lung tumors from patients with SCLC. The overexpression of IFITM1 in DMS273 cells increased their metastatic formation in the orthotopic model and in an experimental metastasis model. Conversely, the silencing of IFITM1 suppressed metastatic formation by DMS273 cells. We also found that IFITM1 overexpression promoted the metastatic formation of NCI-H69 human SCLC cells. These results demonstrate that IFITM1 promotes distant metastasis in xenograft models of human SCLC.
has issue date	2020-07-13(xsd:dateTime)
bibo:doi	10.3390/ijms21144934
bibo:pmid	32668617
has license	cc-by
sha1sum (hex)	8b2955ac317619b637ca2a21bd608fe3da3ae2c0
schema:url	https://doi.org/10.3390/ijms21144934
resource representing a document's title	Interferon-Induced Transmembrane Protein 1 (IFITM1) Promotes Distant Metastasis of Small Cell Lung Cancer
has PubMed Central identifier	PMC7404048
has PubMed identifier	32668617
schema:publication	Int J Mol Sci
resource representing a document's body	covid:8b2955ac317619b637ca2a21bd608fe3da3ae2c0#body_text
is schema:about of	named entity 'bone' named entity 'early' named entity 'metastasis' named entity 'model' named entity 'SCLC' named entity 'tumors' named entity 'RESULTS' named entity 'MORE THAN' named entity 'DMS273' covid:arg/8b2955ac317619b637ca2a21bd608fe3da3ae2c0 named entity 'SCLC' named entity 'formation' named entity 'immunohistochemical' named entity 'transmembrane protein' named entity 'tumors' named entity 'DNA microarray' named entity 'metastatic' named entity 'distant' named entity 'higher' named entity 'expression' named entity 'induced' named entity 'genes' named entity 'cells' named entity 'These' named entity 'models' named entity 'Small Cell' named entity 'Transmembrane' named entity 'IFITM1' named entity 'differentially expressed genes' named entity 'metastatic tumors' named entity 'Small cell lung cancer' named entity 'RNA' named entity 'SCLC' named entity 'IFITM1' named entity 'tumor cell' named entity 'SCLC' named entity 'xenograft models' named entity 'DNA microarray analysis' named entity 'metastasis' named entity 'upregulated' named entity 'protein' named entity 'Transmembrane Protein' named entity 'Metastasis' named entity 'head and neck cancer' named entity 'subcutaneous' named entity 'IFITM1' named entity 'metastasis' named entity 'IFITM1' named entity 'lungs' named entity 'NSCLC' named entity 'transfected' named entity 'Japan' named entity 'adhesion' named entity 'metastases' named entity 'shRNAs' named entity 'MTT assay' named entity 'ovaries' named entity 'primary antibody' named entity 'DMEM' named entity 'Thermal Cycler' named entity 'transfected' named entity 'metastasis' named entity 'IFITM1' named entity 'metastasis' named entity 'SCLC' named entity 'SCLC' named entity 'differentially expressed genes' named entity 'IFITM1' named entity 'hepatocytes' named entity 'SCLC' named entity 'ovarian cancer' named entity 'Immunohistochemical staining' named entity 'metastatic tumors' named entity 'serum' named entity 'tumor metastasis' named entity 'metastasis'

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